Telomerase and the aging process

Peter J. Hornsby

doi:10.1016/j.exger.2007.03.007

Telomerase and the aging process

Peter J. Hornsby

Barshop Institute

Research output: Contribution to journal › Short survey › peer-review

88 Scopus citations

Abstract

The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed.

Original language	English (US)
Pages (from-to)	575-581
Number of pages	7
Journal	Experimental Gerontology
Volume	42
Issue number	7
DOIs	https://doi.org/10.1016/j.exger.2007.03.007
State	Published - Jul 2007

Keywords

Cancer
Immortalization
Senescence
Telomerase
Telomeres

ASJC Scopus subject areas

Genetics
Endocrinology
Aging
Molecular Biology
Biochemistry
Cell Biology

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10.1016/j.exger.2007.03.007

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title = "Telomerase and the aging process",

abstract = "The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed.",

keywords = "Cancer, Immortalization, Senescence, Telomerase, Telomeres",

author = "Hornsby, {Peter J.}",

note = "Funding Information: Work from the author{\textquoteright}s lab cited here was supported by grants from the National Institute on Aging (AG12287 and AG20752) and by a Senior Scholar Award from the Ellison Medical Foundation.",

year = "2007",

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doi = "10.1016/j.exger.2007.03.007",

language = "English (US)",

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T1 - Telomerase and the aging process

AU - Hornsby, Peter J.

N1 - Funding Information: Work from the author’s lab cited here was supported by grants from the National Institute on Aging (AG12287 and AG20752) and by a Senior Scholar Award from the Ellison Medical Foundation.

PY - 2007/7

Y1 - 2007/7

N2 - The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed.

AB - The level of telomerase activity is important in determining telomere length in aging cells and tissues. Here evidence on the importance of telomerase activity is reviewed with respect to aging rates of mammalian species and the health and life span of individuals within a species. The significance of telomerase reactivation for both cancer development and for immortalizing cells for therapeutic processes is assessed.

KW - Cancer

KW - Immortalization

KW - Senescence

KW - Telomerase

KW - Telomeres

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U2 - 10.1016/j.exger.2007.03.007

DO - 10.1016/j.exger.2007.03.007

M3 - Short survey

C2 - 17482404

AN - SCOPUS:34248526205

SN - 0531-5565

VL - 42

SP - 575

EP - 581

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 7

ER -

Telomerase and the aging process

Abstract

Keywords

ASJC Scopus subject areas

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