Telangiectasia and von Willebrand's disease in two families

C. L. Conlon, R. S. Weinger, P. L. Cimo, J. L. Moake, John D Olson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Two families are described with members who have both von Willebrand's disease and telangiectasias. Family A has four members in three consecutive generations that have both von Willebrand's disease and telangiectasias. Von Willebrand's disease in this family is characterized by decreased ristocetin cofactor (FVIII-vWF), variably depressed factor VIII coagulant (FVIII-AHG), and factor VIII-related antigen (FVIII-AGN) levels. FVIII-AGN mobility on two-dimensional crossed immunoelectrophoresis was found to be normal. Four generations in Family B have von Willebrand's disease characterized by decreased FVIII-AHG, FVIII-vWF, FVIII-AGN, and prolonged template bleeding times. Two members of this family also have telangiectasias and recurrent gastrointestinal bleeding. Results in these two families suggest an association between von Willebrand's disease and telangiectasia, perhaps a defect in vascular endothelial cell function.

Original languageEnglish (US)
Pages (from-to)921-924
Number of pages4
JournalAnnals of Internal Medicine
Volume89
Issue number6
StatePublished - 1978
Externally publishedYes

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von Willebrand Diseases
Telangiectasis
von Willebrand Factor
Two-Dimensional Immunoelectrophoresis
Coagulants
Bleeding Time
Factor VIII
Endothelial Cells
Hemorrhage

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Conlon, C. L., Weinger, R. S., Cimo, P. L., Moake, J. L., & Olson, J. D. (1978). Telangiectasia and von Willebrand's disease in two families. Annals of Internal Medicine, 89(6), 921-924.

Telangiectasia and von Willebrand's disease in two families. / Conlon, C. L.; Weinger, R. S.; Cimo, P. L.; Moake, J. L.; Olson, John D.

In: Annals of Internal Medicine, Vol. 89, No. 6, 1978, p. 921-924.

Research output: Contribution to journalArticle

Conlon, CL, Weinger, RS, Cimo, PL, Moake, JL & Olson, JD 1978, 'Telangiectasia and von Willebrand's disease in two families', Annals of Internal Medicine, vol. 89, no. 6, pp. 921-924.
Conlon CL, Weinger RS, Cimo PL, Moake JL, Olson JD. Telangiectasia and von Willebrand's disease in two families. Annals of Internal Medicine. 1978;89(6):921-924.
Conlon, C. L. ; Weinger, R. S. ; Cimo, P. L. ; Moake, J. L. ; Olson, John D. / Telangiectasia and von Willebrand's disease in two families. In: Annals of Internal Medicine. 1978 ; Vol. 89, No. 6. pp. 921-924.
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