Tau pathology mediates age effects on medial temporal lobe structure

Alzheimers Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

Abstract

Hippocampal atrophy is endemic in ‘normal aging’ but it is unclear what factors drive age-related changes in medial temporal lobe (MTL) structural measures. We investigated cross-sectional (n = 191) and longitudinal (n = 164) MTL atrophy patterns in cognitively normal older adults from ADNI-GO/2 with no to low cerebral β-amyloid and assessed whether white matter hyperintensities (WMHs) and cerebrospinal fluid (CSF) phospho tau (p-tau) levels can explain age-related changes in the MTL. Age was significantly associated with hippocampal volumes and Brodmann Area (BA) 35 thickness, regions affected early by neurofibrillary tangle pathology, in the cross-sectional analysis and with anterior and/or posterior hippocampus, entorhinal cortex and BA35 in the longitudinal analysis. CSF p-tau was significantly associated with hippocampal volumes and atrophy rates. Mediation analyses showed that CSF p-tau levels partially mediated age effects on hippocampal atrophy rates. No significant associations were observed for WMHs. These findings point toward a role of tau pathology, potentially reflecting Primary Age-Related Tauopathy, in age-related MTL structural changes and suggests a potential role for tau-targeted interventions in age-associated neurodegeneration and memory decline.

Original languageEnglish (US)
Pages (from-to)135-144
Number of pages10
JournalNeurobiology of Aging
Volume109
DOIs
StatePublished - Jan 2022

Keywords

  • Aging
  • Longitudinal
  • Medial temporal lobe
  • Phospho-tau
  • Primary age-related tauopathy
  • White matter hyperintensities

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Tau pathology mediates age effects on medial temporal lobe structure'. Together they form a unique fingerprint.

Cite this