Targeting the homologous recombination pathway by small molecule modulators

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

During the last decade, the use of small molecule (MW <500 Da) compounds that modulate (inhibit or activate) important proteins of different biological pathways became widespread. Recently, the homologous recombination (HR) pathway emerged as a target for such modulators. Development of small molecule modulators pursues two distinct but not mutually exclusive purposes: to create a research tool to study the activities or functions of proteins of interest and to produce drugs targeting specific pathologies. Here, we review the progress of small molecule development in the area of HR.

Original languageEnglish (US)
Pages (from-to)3006-3013
Number of pages8
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number14
DOIs
StatePublished - Jul 15 2014
Externally publishedYes

Keywords

  • BLM
  • DNA double stranded breaks
  • DNA repair
  • RAD51
  • RAD54
  • WRN

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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