Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

Kai Uwe Lewandrowski; Kenneth Blum; Alexander P.L. Lewandrowski; Panayotis K. Thanos; Albert Pinhasov; Alireza Sharafshah; David Baron; Mark S. Gold; Catherine A. Dennen; Igor Elman; Aballa Bowirrat; Edward J. Modestino; Foojan Zeine; Nicole Jafari; Keerthy Sunder; Milan T. Makale; John Giordano; Marjorie C. Gondre-Lewis; Marco Lindenau; Brian S. Fuehrlein; Rajendra D. Badgaiyan; Chynna Levin; Sergio Luis Schmidt; Rossano Kepler Alvim Fiorelli

doi:10.3389/fpubh.2025.1594872

Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

Kai Uwe Lewandrowski
, Kenneth Blum
, Alexander P.L. Lewandrowski
, Panayotis K. Thanos
, Albert Pinhasov
, Alireza Sharafshah
, David Baron
, Mark S. Gold
, Catherine A. Dennen
, Igor Elman
, Aballa Bowirrat
, Edward J. Modestino
, Foojan Zeine
, Nicole Jafari
, Keerthy Sunder
, Milan T. Makale
, John Giordano
, Marjorie C. Gondre-Lewis
, Marco Lindenau
, Brian S. Fuehrlein

Rajendra D. Badgaiyan, Chynna Levin, Sergio Luis Schmidt, Rossano Kepler Alvim Fiorelli

Research output: Contribution to journal › Comment/debate › peer-review

Original language	English (US)
Article number	1594872
Journal	Frontiers in Public Health
Volume	13
DOIs	https://doi.org/10.3389/fpubh.2025.1594872
State	Published - 2025
Externally published	Yes

Keywords

Reward Deficiency Syndrome (RDS)
addiction and mood disorders
dopamine D2 receptor (DRD2)
genetic predisposition
hypodopaminergia
neurotransmitter regulation
pro-dopaminergic therapy
stress induced anxiety

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.3389/fpubh.2025.1594872

Cite this

Lewandrowski, K. U., Blum, K., Lewandrowski, A. P. L., Thanos, P. K., Pinhasov, A., Sharafshah, A., Baron, D., Gold, M. S., Dennen, C. A., Elman, I., Bowirrat, A., Modestino, E. J., Zeine, F., Jafari, N., Sunder, K., Makale, M. T., Giordano, J., Gondre-Lewis, M. C., Lindenau, M., ... Fiorelli, R. K. A. (2025). Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia. Frontiers in Public Health, 13, Article 1594872. https://doi.org/10.3389/fpubh.2025.1594872

Lewandrowski, KU, Blum, K, Lewandrowski, APL, Thanos, PK, Pinhasov, A, Sharafshah, A, Baron, D, Gold, MS, Dennen, CA, Elman, I, Bowirrat, A, Modestino, EJ, Zeine, F, Jafari, N, Sunder, K, Makale, MT, Giordano, J, Gondre-Lewis, MC, Lindenau, M, Fuehrlein, BS, Badgaiyan, RD, Levin, C, Schmidt, SL & Fiorelli, RKA 2025, 'Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia', Frontiers in Public Health, vol. 13, 1594872. https://doi.org/10.3389/fpubh.2025.1594872

@article{93f6515559f24fe2885bc750e6458049,

title = "Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia",

keywords = "Reward Deficiency Syndrome (RDS), addiction and mood disorders, dopamine D2 receptor (DRD2), genetic predisposition, hypodopaminergia, neurotransmitter regulation, pro-dopaminergic therapy, stress induced anxiety",

author = "Lewandrowski, \{Kai Uwe\} and Kenneth Blum and Lewandrowski, \{Alexander P.L.\} and Thanos, \{Panayotis K.\} and Albert Pinhasov and Alireza Sharafshah and David Baron and Gold, \{Mark S.\} and Dennen, \{Catherine A.\} and Igor Elman and Aballa Bowirrat and Modestino, \{Edward J.\} and Foojan Zeine and Nicole Jafari and Keerthy Sunder and Makale, \{Milan T.\} and John Giordano and Gondre-Lewis, \{Marjorie C.\} and Marco Lindenau and Fuehrlein, \{Brian S.\} and Badgaiyan, \{Rajendra D.\} and Chynna Levin and Schmidt, \{Sergio Luis\} and Fiorelli, \{Rossano Kepler Alvim\}",

year = "2025",

doi = "10.3389/fpubh.2025.1594872",

language = "English (US)",

volume = "13",

journal = "Frontiers in Public Health",

issn = "2296-2565",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

AU - Lewandrowski, Kai Uwe

AU - Blum, Kenneth

AU - Lewandrowski, Alexander P.L.

AU - Thanos, Panayotis K.

AU - Pinhasov, Albert

AU - Sharafshah, Alireza

AU - Baron, David

AU - Gold, Mark S.

AU - Dennen, Catherine A.

AU - Elman, Igor

AU - Bowirrat, Aballa

AU - Modestino, Edward J.

AU - Zeine, Foojan

AU - Jafari, Nicole

AU - Sunder, Keerthy

AU - Makale, Milan T.

AU - Giordano, John

AU - Gondre-Lewis, Marjorie C.

AU - Lindenau, Marco

AU - Fuehrlein, Brian S.

AU - Badgaiyan, Rajendra D.

AU - Levin, Chynna

AU - Schmidt, Sergio Luis

AU - Fiorelli, Rossano Kepler Alvim

PY - 2025

Y1 - 2025

KW - Reward Deficiency Syndrome (RDS)

KW - addiction and mood disorders

KW - dopamine D2 receptor (DRD2)

KW - genetic predisposition

KW - hypodopaminergia

KW - neurotransmitter regulation

KW - pro-dopaminergic therapy

KW - stress induced anxiety

UR - https://www.scopus.com/pages/publications/105018527910

UR - https://www.scopus.com/pages/publications/105018527910#tab=citedBy

U2 - 10.3389/fpubh.2025.1594872

DO - 10.3389/fpubh.2025.1594872

M3 - Comment/debate

C2 - 41080838

AN - SCOPUS:105018527910

SN - 2296-2565

VL - 13

JO - Frontiers in Public Health

JF - Frontiers in Public Health

M1 - 1594872

ER -

Targeting pro-dopaminergic agonism to attenuate and depression in patient's displaying genetic/epigenetic predisposition to hypodopaminergia

Keywords

ASJC Scopus subject areas

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