Targeting angiogenesis in head and neck cancer

Maria Vassilakopoulou; Amanda Psyrri; Athanassios Argiris

doi:10.1016/j.oraloncology.2015.01.006

Targeting angiogenesis in head and neck cancer

Maria Vassilakopoulou, Amanda Psyrri, Athanassios Argiris

Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Angiogenesis is a crucial step in tumor growth and metastasis. Head and neck squamous cell carcinomas (HNSCC) highly express angiogenesis factors, such as vascular endothelial growth factor (VEGF), which are associated with patient prognosis. Antiangiogenesis agents can potentially modulate tumor microenvironment and induce radiosensitivity and chemosensitivity. In this review, we discuss the molecular mechanisms underlying angiogenesis involved in HNSCC, preclinical data with antiangiogenesis agents as well as potential predictive biomarkers. We also review novel therapies under investigation and summarize the results of clinical trials using antiangiogenesis agents alone or in combination with conventional therapies in HNSCC.

Original language	English (US)
Pages (from-to)	409-415
Number of pages	7
Journal	Oral Oncology
Volume	51
Issue number	5
DOIs	https://doi.org/10.1016/j.oraloncology.2015.01.006
State	Published - 2015

Keywords

Angiogenesis
Bevacizumab
Head and neck cancer
Monoclonal antibodies
Targeted therapy
Tyrosine kinase inhibitors
Vascular endothelial growth factor
Vascular endothelial growth factor receptor

ASJC Scopus subject areas

Oncology
Oral Surgery
Cancer Research

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title = "Targeting angiogenesis in head and neck cancer",

abstract = "Angiogenesis is a crucial step in tumor growth and metastasis. Head and neck squamous cell carcinomas (HNSCC) highly express angiogenesis factors, such as vascular endothelial growth factor (VEGF), which are associated with patient prognosis. Antiangiogenesis agents can potentially modulate tumor microenvironment and induce radiosensitivity and chemosensitivity. In this review, we discuss the molecular mechanisms underlying angiogenesis involved in HNSCC, preclinical data with antiangiogenesis agents as well as potential predictive biomarkers. We also review novel therapies under investigation and summarize the results of clinical trials using antiangiogenesis agents alone or in combination with conventional therapies in HNSCC.",

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AU - Psyrri, Amanda

AU - Argiris, Athanassios

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AB - Angiogenesis is a crucial step in tumor growth and metastasis. Head and neck squamous cell carcinomas (HNSCC) highly express angiogenesis factors, such as vascular endothelial growth factor (VEGF), which are associated with patient prognosis. Antiangiogenesis agents can potentially modulate tumor microenvironment and induce radiosensitivity and chemosensitivity. In this review, we discuss the molecular mechanisms underlying angiogenesis involved in HNSCC, preclinical data with antiangiogenesis agents as well as potential predictive biomarkers. We also review novel therapies under investigation and summarize the results of clinical trials using antiangiogenesis agents alone or in combination with conventional therapies in HNSCC.

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KW - Bevacizumab

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KW - Vascular endothelial growth factor receptor

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