Targeting β-cell mass in type 2 diabetes: Promise and limitations of new drugs based on incretins

Marzieh Salehi; Benedikt A. Aulinger; David A. D'Alessio

doi:10.1210/er.2007-0031

Targeting β-cell mass in type 2 diabetes: Promise and limitations of new drugs based on incretins

Marzieh Salehi, Benedikt A. Aulinger, David A. D'Alessio

Research output: Contribution to journal › Review article › peer-review

97 Scopus citations

Abstract

Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based drugs hold the potential to improve glucose tolerance by immediate favorable effect on β-cell physiology as well as by expanding or at least maintaining β-cell mass, which may delay the progression of the disease. Long-term studies in humans are needed to elaborate on these effects.

Original language	English (US)
Pages (from-to)	367-379
Number of pages	13
Journal	Endocrine Reviews
Volume	29
Issue number	3
DOIs	https://doi.org/10.1210/er.2007-0031
State	Published - May 2008
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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abstract = "Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based drugs hold the potential to improve glucose tolerance by immediate favorable effect on β-cell physiology as well as by expanding or at least maintaining β-cell mass, which may delay the progression of the disease. Long-term studies in humans are needed to elaborate on these effects.",

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AU - D'Alessio, David A.

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AB - Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based drugs hold the potential to improve glucose tolerance by immediate favorable effect on β-cell physiology as well as by expanding or at least maintaining β-cell mass, which may delay the progression of the disease. Long-term studies in humans are needed to elaborate on these effects.

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Targeting β-cell mass in type 2 diabetes: Promise and limitations of new drugs based on incretins

Abstract

ASJC Scopus subject areas

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