Taquicardia ventricular polimórfica catecolaminérgica

Translated title of the contribution: Catecholaminergic polymorphic ventricular tachycardia

Alejandro Velasco, Víctor M. Velasco, Fernando Rosas, Juan F. Betancourt, Juan Baena, Alexander Álvarez, Alirio Balanta

Research output: Contribution to journalArticlepeer-review


Catecholaminergic Polymorphic Ventricular Tachycardia is an inherited heart rhythm disorder recently discovered by genetic and electrophysiological diagnostic advancements. It consists of an inherited disorder characterized by the induction of bi-directional ventricular tachycardia in the presence of catecholamines, without a structural cardiac abnormality. Mutations in the Ryanodine receptor gene RyR2, have been linked with an autosomic dominant form, while mutations in the Calsequestrin gene CASQ 2 have showed correlation with an autosomic recessive form. The average age of onset is between 7 and 9 years of age, and clinical symptoms vary from syncope to sudden cardiac death. The diagnosis is confirmed by inducting ventricular tachycardia through a stress test or during an infusion of sympathicomimetic drugs like Isoproterenol, aided by the identification of mutations in the RyR2 and CASQ2 genes through gene analysis. Implantable cardiodefibrillator devices remain a valid therapeutic option in many cases due to the fact that antiarrhythmic drugs have not shown efficacy. Sympathetic cardiac denervation can be useful in some special cases. Catecholaminergic Polymorphic Ventricular Tachycardia opens a wide field for the development of new antiarrhythmic drugs and the use of gene therapy for cardiac rhythm disorders.

Translated title of the contributionCatecholaminergic polymorphic ventricular tachycardia
Original languageSpanish
Pages (from-to)71-75
Number of pages5
JournalRevista Colombiana de Cardiologia
Issue number2
StatePublished - Apr 2009
Externally publishedYes


  • Genetic
  • Polymorphic ventricular tachycardia
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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