TY - JOUR
T1 - Take the monkey and run
AU - Phillips, Kimberley A.
AU - Hambright, M. Karen
AU - Hewes, Kelly
AU - Schilder, Brian M.
AU - Ross, Corinna N.
AU - Tardif, Suzette D.
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/6/5
Y1 - 2015/6/5
N2 - Background: The common marmoset (Callithrix jacchus) is a small, New World primate that is used extensively in biomedical and behavioral research. This short-lived primate, with its small body size, ease of handling, and docile temperament, has emerged as a valuable model for aging and neurodegenerative research.A growing body of research has indicated exercise, aerobic exercise especially, imparts beneficial effects to normal aging. Understanding the mechanisms underlying these positive effects of exercise, and the degree to which exercise has neurotherapeutic effects, is an important research focus. Thus, developing techniques to engage marmosets in aerobic exercise would have great advantages. New method: Here we describe the marmoset exercise ball (MEB) paradigm: a safe (for both experimenter and subjects), novel and effective means to engage marmosets in aerobic exercise. We trained young adult male marmosets to run on treadmills for 30. min a day, 3 days a week. Results: Our training procedures allowed us to engage male marmosets in this aerobic exercise within 4 weeks, and subjects maintained this frequency of exercise for 3 months. Comparison with existing methods: To our knowledge, this is the first described method to engage marmosets in aerobic exercise. A major advantage of this exercise paradigm is that while it was technically forced exercise, it did not appear to induce stress in the marmosets. Conclusions: These techniques should be useful to researchers wishing to address physiological responses of exercise in a marmoset model.
AB - Background: The common marmoset (Callithrix jacchus) is a small, New World primate that is used extensively in biomedical and behavioral research. This short-lived primate, with its small body size, ease of handling, and docile temperament, has emerged as a valuable model for aging and neurodegenerative research.A growing body of research has indicated exercise, aerobic exercise especially, imparts beneficial effects to normal aging. Understanding the mechanisms underlying these positive effects of exercise, and the degree to which exercise has neurotherapeutic effects, is an important research focus. Thus, developing techniques to engage marmosets in aerobic exercise would have great advantages. New method: Here we describe the marmoset exercise ball (MEB) paradigm: a safe (for both experimenter and subjects), novel and effective means to engage marmosets in aerobic exercise. We trained young adult male marmosets to run on treadmills for 30. min a day, 3 days a week. Results: Our training procedures allowed us to engage male marmosets in this aerobic exercise within 4 weeks, and subjects maintained this frequency of exercise for 3 months. Comparison with existing methods: To our knowledge, this is the first described method to engage marmosets in aerobic exercise. A major advantage of this exercise paradigm is that while it was technically forced exercise, it did not appear to induce stress in the marmosets. Conclusions: These techniques should be useful to researchers wishing to address physiological responses of exercise in a marmoset model.
KW - Aging research
KW - Exercise
KW - Marmoset (Callithrix jacchus)
KW - Primate models
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U2 - 10.1016/j.jneumeth.2015.03.023
DO - 10.1016/j.jneumeth.2015.03.023
M3 - Article
C2 - 25835199
AN - SCOPUS:84927647579
SN - 0165-0270
VL - 248
SP - 27
EP - 31
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
ER -