Taccalonolides: Novel microtubule stabilizers with clinical potential

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Nature remains an important source for new anticancer drugs. Numerous microtubule-targeting agents currently approved or in clinical development, including paclitaxel, vinblastine, vincristine, colchicine and combretastatin, are plant-derived compounds. The microtubule stabilizing properties of the taccalonolides were discovered as a part of a program to identify new microtubule stabilizers from natural sources. The taccalonolides are unique among all other agents in this class in that they stabilize microtubules through a mechanism of action that does not involve direct tubulin binding. Herein we review the discovery and isolation of the taccalonolides, their biological activities in vitro and in vivo and their potential advantages over clinically used microtubule stabilizers. We also discuss the challenges in formulation and supply that will need to be solved before the taccalonolides can become candidates for clinical development.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalCancer Letters
Volume291
Issue number1
DOIs
StatePublished - May 1 2010

Keywords

  • Drug resistance
  • Microtubule stabilizers
  • Microtubules
  • Taccalonolides

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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