T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

Aline Silva de Miranda; Rodrigo Novaes Ferreira; Érica Leandro Marciano Vieira; Larissa Katharina Sabino Abreu; Fátima Brant; Luciene Bruno Vieira; Fabíola Mara Ribeiro; Fabiana Simão Machado; Milene Alvarenga Rachid; Antônio Lúcio Teixeira

doi:10.1016/j.jneuroim.2019.02.002

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

Aline Silva de Miranda
, Rodrigo Novaes Ferreira
, Érica Leandro Marciano Vieira
, Larissa Katharina Sabino Abreu
, Fátima Brant
, Luciene Bruno Vieira
, Fabíola Mara Ribeiro
, Fabiana Simão Machado
, Milene Alvarenga Rachid
, Antônio Lúcio Teixeira

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.

Original language	English (US)
Pages (from-to)	5-11
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	330
DOIs	https://doi.org/10.1016/j.jneuroim.2019.02.002
State	Published - May 15 2019
Externally published	Yes

Keywords

Cerebral malaria
Chloroquine
Glutamate
MK801
Malaria
T lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2019.02.002

Cite this

de Miranda, A. S., Ferreira, R. N., Vieira, É. L. M., Abreu, L. K. S., Brant, F., Vieira, L. B., Ribeiro, F. M., Machado, F. S., Rachid, M. A., & Teixeira, A. L. (2019). T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes. Journal of Neuroimmunology, 330, 5-11. https://doi.org/10.1016/j.jneuroim.2019.02.002

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes. / de Miranda, Aline Silva; Ferreira, Rodrigo Novaes; Vieira, Érica Leandro Marciano et al.
In: Journal of Neuroimmunology, Vol. 330, 15.05.2019, p. 5-11.

Research output: Contribution to journal › Article › peer-review

de Miranda, AS, Ferreira, RN, Vieira, ÉLM, Abreu, LKS, Brant, F, Vieira, LB, Ribeiro, FM, Machado, FS, Rachid, MA & Teixeira, AL 2019, 'T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes', Journal of Neuroimmunology, vol. 330, pp. 5-11. https://doi.org/10.1016/j.jneuroim.2019.02.002

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title = "T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes",

abstract = "Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.",

keywords = "Cerebral malaria, Chloroquine, Glutamate, MK801, Malaria, T lymphocytes",

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AU - de Miranda, Aline Silva

AU - Ferreira, Rodrigo Novaes

AU - Vieira, Érica Leandro Marciano

AU - Abreu, Larissa Katharina Sabino

AU - Brant, Fátima

AU - Vieira, Luciene Bruno

AU - Ribeiro, Fabíola Mara

AU - Machado, Fabiana Simão

AU - Rachid, Milene Alvarenga

AU - Teixeira, Antônio Lúcio

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AB - Several studies have proposed cerebral malaria (CM) as a CD4+ and CD8+ T lymphocyte-mediated disease. However, there are no data regarding the recruitment and/or persistence of these cells in the CNS following the phase of infection resolution. Glutamate-mediate excitotoxicity has also been implicated in CM. Blockade of glutamate NMDA receptors by its noncompetitive antagonist MK801 modulates cytokine and neurotrophic factors expression preventing cognitive and depressive-like behavior in experimental CM. Herein, we aim to investigate the role of T lymphocytes in later outcomes in CM, and whether the protective role of MK801 is associated with T lymphocytes response.

KW - Cerebral malaria

KW - Chloroquine

KW - Glutamate

KW - MK801

KW - Malaria

KW - T lymphocytes

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ER -

T-lymphocytes response persists following Plasmodium berghei strain Anka infection resolution and may contribute to later experimental cerebral malaria outcomes

Abstract

Keywords

ASJC Scopus subject areas

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