T-cell lymphoma and the virus-associated hemophagocytic syndrome

F. E. Craig, C. N. Clare, J. L. Sklar, P. M. Banks

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


A 20-month-old girl had a disorder that by both clinical and histologic criteria resembled the virus-associated hemophagocytic syndrome in the setting of Epstein-Barr virus infection. Subsequent investigation revealed histologic evidence of disseminated T-cell lymphoma. DNA hybridization studies displayed a monoclonal T-cell receptor beta chain rearrangement, in the absence of clonal immunoglobulin gene rearrangement, and a single band in the analysis for the fused termini of the Epstein-Barr virus genome. These results suggest the presence of a monoclonal population of T lymphocytes infected with Epstein-Barr virus. The diagnosis of lymphoma was confirmed at autopsy. The authors discuss the association of Epstein-Barr virus infection with the development of T-cell lymphoma and propose that the previous reports of virus-associated hemophagocytic syndrome include cases of unrecognized T-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - 1992


  • Epstein-Barr virus
  • Hemophagocytic syndrome
  • T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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