T cell hybridomas reactive with the acetylcholine receptor and its subunits

J. A. Tami, O. E. Urso, K. A. Krolick

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A panel of thirty cloned rat-mouse T cell hybridomas was prepared by fusion acetylcholine receptor (AChR)-reactive rat T cells with the mouse thymoma BW5147. The T cell hybrids were demonstrated to be AChR reactive by their ability to secrete IL 2 in response to either AChR itself or by purified AChR subunits (α,β,γ, or δ). Various patterns of AChR subunit reactivity were observed, suggesting a predominant recognition of the α subunit, and also a considerable cross-reactivity from one subunit to another.

Original languageEnglish (US)
Pages (from-to)732-738
Number of pages7
JournalJournal of Immunology
Volume138
Issue number3
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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