T cell hybridomas reactive with the acetylcholine receptor and its subunits

J. A. Tami; O. E. Urso; K. A. Krolick

T cell hybridomas reactive with the acetylcholine receptor and its subunits

J. A. Tami, O. E. Urso, K. A. Krolick

Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A panel of thirty cloned rat-mouse T cell hybridomas was prepared by fusion acetylcholine receptor (AChR)-reactive rat T cells with the mouse thymoma BW5147. The T cell hybrids were demonstrated to be AChR reactive by their ability to secrete IL 2 in response to either AChR itself or by purified AChR subunits (α,β,γ, or δ). Various patterns of AChR subunit reactivity were observed, suggesting a predominant recognition of the α subunit, and also a considerable cross-reactivity from one subunit to another.

Original language	English (US)
Pages (from-to)	732-738
Number of pages	7
Journal	Journal of Immunology
Volume	138
Issue number	3
State	Published - Jan 1 1987

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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AB - A panel of thirty cloned rat-mouse T cell hybridomas was prepared by fusion acetylcholine receptor (AChR)-reactive rat T cells with the mouse thymoma BW5147. The T cell hybrids were demonstrated to be AChR reactive by their ability to secrete IL 2 in response to either AChR itself or by purified AChR subunits (α,β,γ, or δ). Various patterns of AChR subunit reactivity were observed, suggesting a predominant recognition of the α subunit, and also a considerable cross-reactivity from one subunit to another.

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T cell hybridomas reactive with the acetylcholine receptor and its subunits

Abstract

ASJC Scopus subject areas

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