A panel of thirty cloned rat-mouse T cell hybridomas was prepared by fusion acetylcholine receptor (AChR)-reactive rat T cells with the mouse thymoma BW5147. The T cell hybrids were demonstrated to be AChR reactive by their ability to secrete IL 2 in response to either AChR itself or by purified AChR subunits (α,β,γ, or δ). Various patterns of AChR subunit reactivity were observed, suggesting a predominant recognition of the α subunit, and also a considerable cross-reactivity from one subunit to another.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Immunology|
|State||Published - Jan 1 1987|
ASJC Scopus subject areas
- Immunology and Allergy