Abstract
A panel of thirty cloned rat-mouse T cell hybridomas was prepared by fusion acetylcholine receptor (AChR)-reactive rat T cells with the mouse thymoma BW5147. The T cell hybrids were demonstrated to be AChR reactive by their ability to secrete IL 2 in response to either AChR itself or by purified AChR subunits (α,β,γ, or δ). Various patterns of AChR subunit reactivity were observed, suggesting a predominant recognition of the α subunit, and also a considerable cross-reactivity from one subunit to another.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 732-738 |
| Number of pages | 7 |
| Journal | Journal of Immunology |
| Volume | 138 |
| Issue number | 3 |
| State | Published - Jan 1 1987 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Tami, J. A., Urso, O. E., & Krolick, K. A. (1987). T cell hybridomas reactive with the acetylcholine receptor and its subunits. Journal of Immunology, 138(3), 732-738.