Abstract
A panel of thirty cloned rat-mouse T cell hybridomas was prepared by fusion acetylcholine receptor (AChR)-reactive rat T cells with the mouse thymoma BW5147. The T cell hybrids were demonstrated to be AChR reactive by their ability to secrete IL 2 in response to either AChR itself or by purified AChR subunits (α,β,γ, or δ). Various patterns of AChR subunit reactivity were observed, suggesting a predominant recognition of the α subunit, and also a considerable cross-reactivity from one subunit to another.
Original language | English (US) |
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Pages (from-to) | 732-738 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 138 |
Issue number | 3 |
State | Published - Jan 1 1987 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology