T-cell acute lymphoblastic leukemia: A report of 60 patients from India

S. H. Advani, D. M. Kamat, D. N. Rao, R. Gopal, C. N. Nair, T. Saikia

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

60 patients studied at the Tata Memorial Hospital from January 1976 to December 1982 were diagnosed as having T-cell acute lymphoblastic leukemia (ALL) by nonimmune rosette formation with sheep red blood cells. The analysis revealed a high incidence of mediastinal mass (50%) and extramedullary infiltration at presentation. The majority of patients (62%) presented with a high WBC count (>50,000/mm3). Unipolar acid phosphatase activity was observed in 90% of patients. The remission rate with a combination treatment of adriamycin, vincristine and prednisolone was found to be 95%. Long-term survival was around 30%. More aggressive or innovative treatments will be needed to improve the results in T-cell ALL.

Original languageEnglish (US)
Pages (from-to)282-287
Number of pages6
JournalOncology
Volume42
Issue number5
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Advani, S. H., Kamat, D. M., Rao, D. N., Gopal, R., Nair, C. N., & Saikia, T. (1985). T-cell acute lymphoblastic leukemia: A report of 60 patients from India. Oncology, 42(5), 282-287. https://doi.org/10.1159/000226047