Systemic antifungal agents

Russell E. Lewis; Nathan P. Wiederhold

doi:10.1007/978-3-031-35803-6_8

Systemic antifungal agents

Russell E. Lewis, Nathan P. Wiederhold

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Systemic antifungal drugs used to treat serious fungal disease fall chiefly into three drug classes-azoles, echinocandins, and polyenes. A fourth class, pyrimidine analogues, consists of a single agent, flucytosine, that is only used in combination with other antifungals. Both azoles and polyenes target the cell membrane, while echinocandins specifically target cell wall synthesis. This chapter details drugs mechanisms of action, spectrum of activity, pharmacokinetics, and toxicities associated with the clinical use of currently approved systemic antifungals to treat life-threatening mycoses. In addition to drug characteristics, the detection and interpretation of antifungal resistance is discussed for common clinically relevant species.

Original language	English (US)
Title of host publication	Diagnosis and Treatment of Fungal Infections
Subtitle of host publication	Third Edition
Publisher	Springer International Publishing
Pages	125-147
Number of pages	23
ISBN (Electronic)	9783031358036
ISBN (Print)	9783031358029
DOIs	https://doi.org/10.1007/978-3-031-35803-6_8
State	Published - Sep 14 2023

Keywords

Adverse reactions
Allylamine
Antifungal
Azole
Drug interactions
Echinocandin
Mechanism of action
Pharmacokinetics
Polyene
Resistance
Susceptibility

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-031-35803-6_8

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abstract = "Systemic antifungal drugs used to treat serious fungal disease fall chiefly into three drug classes-azoles, echinocandins, and polyenes. A fourth class, pyrimidine analogues, consists of a single agent, flucytosine, that is only used in combination with other antifungals. Both azoles and polyenes target the cell membrane, while echinocandins specifically target cell wall synthesis. This chapter details drugs mechanisms of action, spectrum of activity, pharmacokinetics, and toxicities associated with the clinical use of currently approved systemic antifungals to treat life-threatening mycoses. In addition to drug characteristics, the detection and interpretation of antifungal resistance is discussed for common clinically relevant species.",

keywords = "Adverse reactions, Allylamine, Antifungal, Azole, Drug interactions, Echinocandin, Mechanism of action, Pharmacokinetics, Polyene, Resistance, Susceptibility",

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AU - Wiederhold, Nathan P.

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N2 - Systemic antifungal drugs used to treat serious fungal disease fall chiefly into three drug classes-azoles, echinocandins, and polyenes. A fourth class, pyrimidine analogues, consists of a single agent, flucytosine, that is only used in combination with other antifungals. Both azoles and polyenes target the cell membrane, while echinocandins specifically target cell wall synthesis. This chapter details drugs mechanisms of action, spectrum of activity, pharmacokinetics, and toxicities associated with the clinical use of currently approved systemic antifungals to treat life-threatening mycoses. In addition to drug characteristics, the detection and interpretation of antifungal resistance is discussed for common clinically relevant species.

AB - Systemic antifungal drugs used to treat serious fungal disease fall chiefly into three drug classes-azoles, echinocandins, and polyenes. A fourth class, pyrimidine analogues, consists of a single agent, flucytosine, that is only used in combination with other antifungals. Both azoles and polyenes target the cell membrane, while echinocandins specifically target cell wall synthesis. This chapter details drugs mechanisms of action, spectrum of activity, pharmacokinetics, and toxicities associated with the clinical use of currently approved systemic antifungals to treat life-threatening mycoses. In addition to drug characteristics, the detection and interpretation of antifungal resistance is discussed for common clinically relevant species.

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KW - Allylamine

KW - Antifungal

KW - Azole

KW - Drug interactions

KW - Echinocandin

KW - Mechanism of action

KW - Pharmacokinetics

KW - Polyene

KW - Resistance

KW - Susceptibility

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DO - 10.1007/978-3-031-35803-6_8

M3 - Chapter

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SN - 9783031358029

SP - 125

EP - 147

BT - Diagnosis and Treatment of Fungal Infections

PB - Springer International Publishing

ER -

Systemic antifungal agents

Abstract

Keywords

ASJC Scopus subject areas

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