Abstract
The effect of two chemically dissimilar cyclooxygenase inhibitors was studied in pentobarbital-anesthetized endotoxic pigs. Animals in groups II-IV were infused with Escherichia coli lipopolysaccharide (LPS, 150 μg/kg) and resuscitated with normal saline (1.2 ml·kg-1·min-1). Animals in group I (n = 4) were resuscitated as above but were not infused with LPS. Animals in group II (n = 7) served as endotoxic controls. Pigs in groups III (n = 6) and IV (n = 5) were pre-. and posttreated with ibuprofen (10 mg/kg bolus then 10 mg·kg-1·h-1) and meclofenamate (5 mg/kg then 5 mg·kg-1·h-1), respectively. Ileal intramucosal hydrogen ion concentration ([H+]) was estimated tonometrically. In group I, cardiac index (CI), mean arterial pressure (MAP), superior mesenteric arterial perfusion (Q̇SMA), and mesenteric O2 delivery (ḊO2) increased significantly, but other variables were unchanged. After infusion of LPS in group II, MAP and systemic vascular resistance index were markedly diminished but CI was well preserved. In this group, Q̇SMA, systemic ḊO2, and mesenteric ḊO2 decreased, whereas systemic O2 uptake (V̇O2) and gut [H+] increased; mesenteric V̇O2 was unchanged. Compared with pigs in group II, pigs treated with ibuprofen or meclofenamate manifested improved systemic and mesenteric ḊO2. In groups III and IV, Q̇SMA remained normal, increased systemic V̇O2 was not observed, and gut intramucosal acidosis was ameliorated. Increased intramucosal [H+] in group II suggests that Q̇SMA was inadequate. The salutary effects of ibuprofen and meclofenamate suggest that inadequate mesenteric perfusion was mediated, at least in part, by cyclooxygenase-derived metabolites or arachidonic acid.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1950-1957 |
| Number of pages | 8 |
| Journal | Journal of Applied Physiology |
| Volume | 67 |
| Issue number | 5 |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- cyclooxygenase inhibitors
- Ileal intramucosal hydrogen ion concentration
- lipopolysaccharide
- mesenteric perfusion
- prostaglandins
ASJC Scopus subject areas
- Endocrinology
- Physiology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Systemic and mesenteric O2 metabolism in endotoxic pigs : Effect of ibuprofen and meclofenamate. / Fink, M. P.; Rothschild, H. R.; Deniz, Y. F.; Wang, H.; Lee, P. C.; Cohn, S. M.
In: Journal of Applied Physiology, Vol. 67, No. 5, 1989, p. 1950-1957.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Systemic and mesenteric O2 metabolism in endotoxic pigs
T2 - Effect of ibuprofen and meclofenamate
AU - Fink, M. P.
AU - Rothschild, H. R.
AU - Deniz, Y. F.
AU - Wang, H.
AU - Lee, P. C.
AU - Cohn, S. M.
PY - 1989
Y1 - 1989
N2 - The effect of two chemically dissimilar cyclooxygenase inhibitors was studied in pentobarbital-anesthetized endotoxic pigs. Animals in groups II-IV were infused with Escherichia coli lipopolysaccharide (LPS, 150 μg/kg) and resuscitated with normal saline (1.2 ml·kg-1·min-1). Animals in group I (n = 4) were resuscitated as above but were not infused with LPS. Animals in group II (n = 7) served as endotoxic controls. Pigs in groups III (n = 6) and IV (n = 5) were pre-. and posttreated with ibuprofen (10 mg/kg bolus then 10 mg·kg-1·h-1) and meclofenamate (5 mg/kg then 5 mg·kg-1·h-1), respectively. Ileal intramucosal hydrogen ion concentration ([H+]) was estimated tonometrically. In group I, cardiac index (CI), mean arterial pressure (MAP), superior mesenteric arterial perfusion (Q̇SMA), and mesenteric O2 delivery (ḊO2) increased significantly, but other variables were unchanged. After infusion of LPS in group II, MAP and systemic vascular resistance index were markedly diminished but CI was well preserved. In this group, Q̇SMA, systemic ḊO2, and mesenteric ḊO2 decreased, whereas systemic O2 uptake (V̇O2) and gut [H+] increased; mesenteric V̇O2 was unchanged. Compared with pigs in group II, pigs treated with ibuprofen or meclofenamate manifested improved systemic and mesenteric ḊO2. In groups III and IV, Q̇SMA remained normal, increased systemic V̇O2 was not observed, and gut intramucosal acidosis was ameliorated. Increased intramucosal [H+] in group II suggests that Q̇SMA was inadequate. The salutary effects of ibuprofen and meclofenamate suggest that inadequate mesenteric perfusion was mediated, at least in part, by cyclooxygenase-derived metabolites or arachidonic acid.
AB - The effect of two chemically dissimilar cyclooxygenase inhibitors was studied in pentobarbital-anesthetized endotoxic pigs. Animals in groups II-IV were infused with Escherichia coli lipopolysaccharide (LPS, 150 μg/kg) and resuscitated with normal saline (1.2 ml·kg-1·min-1). Animals in group I (n = 4) were resuscitated as above but were not infused with LPS. Animals in group II (n = 7) served as endotoxic controls. Pigs in groups III (n = 6) and IV (n = 5) were pre-. and posttreated with ibuprofen (10 mg/kg bolus then 10 mg·kg-1·h-1) and meclofenamate (5 mg/kg then 5 mg·kg-1·h-1), respectively. Ileal intramucosal hydrogen ion concentration ([H+]) was estimated tonometrically. In group I, cardiac index (CI), mean arterial pressure (MAP), superior mesenteric arterial perfusion (Q̇SMA), and mesenteric O2 delivery (ḊO2) increased significantly, but other variables were unchanged. After infusion of LPS in group II, MAP and systemic vascular resistance index were markedly diminished but CI was well preserved. In this group, Q̇SMA, systemic ḊO2, and mesenteric ḊO2 decreased, whereas systemic O2 uptake (V̇O2) and gut [H+] increased; mesenteric V̇O2 was unchanged. Compared with pigs in group II, pigs treated with ibuprofen or meclofenamate manifested improved systemic and mesenteric ḊO2. In groups III and IV, Q̇SMA remained normal, increased systemic V̇O2 was not observed, and gut intramucosal acidosis was ameliorated. Increased intramucosal [H+] in group II suggests that Q̇SMA was inadequate. The salutary effects of ibuprofen and meclofenamate suggest that inadequate mesenteric perfusion was mediated, at least in part, by cyclooxygenase-derived metabolites or arachidonic acid.
KW - cyclooxygenase inhibitors
KW - Ileal intramucosal hydrogen ion concentration
KW - lipopolysaccharide
KW - mesenteric perfusion
KW - prostaglandins
UR - http://www.scopus.com/inward/record.url?scp=0024854381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024854381&partnerID=8YFLogxK
M3 - Article
C2 - 2513312
AN - SCOPUS:0024854381
VL - 67
SP - 1950
EP - 1957
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 0161-7567
IS - 5
ER -