Systematic analysis of the salutary effect of estrogen on cardiac performance after trauma-hemorrhage

Zheng F. Ba, Jun Te Hsu, Jianguo Chen, Wen Hong Kan, Martin G. Schwacha, Irshad H. Chaudry

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Although 17β-estradiol (estrogen) and estrogen receptor (ER) agonist administration after trauma-hemorrhage improves cardiac function, it remains unknown what the optimal estrogen or ER agonist dosage is to elicit this beneficial effect. To study this, the dose-dependent effects of estrogen, propylpyrazole triol (ER-α agonist), and diarylpropionitrile (DPN; ER-β agonist) on heart performance (+dP/dt) were determined in sham rats and in experimental animals at the time of maximal bleedout (MBO) or at 2 h after trauma-hemorrhage. The results showed that estrogen and DPN induced dose-dependent increases in the maximal rate of left ventricular pressure increase (+dP/dt) in all groups, whereas propylpyrazole triol was ineffective at all doses. The maximal dose and the 50% effective dose of DPN were approximately 100-fold lower than those of estrogen. The half-life of estrogen in plasma was approximately 25 min in sham and MBO groups. A positive correlation between the estrogen-induced increase in +dP/dt and survival in MBO rats were observed. These results collectively suggest that the salutary effects of estrogen on cardiac performance are dose-dependent and mediated via ER-β.

Original languageEnglish (US)
Pages (from-to)585-589
Number of pages5
JournalShock
Volume30
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • +dP/dt
  • Diarylpropionitrile
  • Hemorrhagic shock
  • Propylpyrazole triol

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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