SysMicrO: A novel systems approach for miRNA target prediction

Hui Liu, Lin Zhang, Qilong Sun, Yidong Chen, Yufei Huang

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    MicroRNAs (miRNAs) are single-stranded non-coding RNAs shown to plays important regulatory roles in a wide range of biological processes and diseases. Target prediction is the bottleneck to understand the function of miRNA. Therefore, computational methods have evolved as important tools for genome-wide target screening. Although considerable work in the past few years has produced many target prediction algorithms, it's still hard for biologists to utilize the prediction result to identify miRNA targets. The mainly disadvantage of current target prediction algorithms include: 1 st , most algorithms are solely based on sequence information, 2 nd , accuracy is poor and 3 rd , the prediction results are lacking of biological meaning. A novel systems approach is proposed in this paper that integrates sequence level prediction, gene expression profiling of miRNA transfection as while as knowledge database information, which include signaling pathway and transcription factor regulation information. This systems approach would reduce the false positive rate of target prediction algorithms. More important, the prediction results of this approach will naturally embody gene regulation information, which is convictive guidance for biologist to implement subsequently identification research.

    Original languageEnglish (US)
    Title of host publicationAdvanced Intelligent Computing Theories and Applications
    Subtitle of host publicationWith Aspects of Artificial Intelligence - 6th International Conference on Intelligent Computing, ICIC 2010, Proceedings
    EditorsDe-Shuang Huang, Xiang Zhang
    Pages9-16
    Number of pages8
    DOIs
    StatePublished - 2010
    Event6th International Conference on Intelligent Computing, ICIC 2010 - Changsha, China
    Duration: Aug 18 2010Aug 21 2010

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume6216 LNAI
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Other

    Other6th International Conference on Intelligent Computing, ICIC 2010
    Country/TerritoryChina
    CityChangsha
    Period8/18/108/21/10

    Keywords

    • GSEA
    • Signaling Pathway
    • Transcription factor
    • miRNA

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

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