Synthetic oleanane triterpenoids: Magic bullets or not?

Research output: Contribution to journalComment/debatepeer-review

10 Scopus citations

Abstract

A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

Original languageEnglish (US)
Pages (from-to)785-787
Number of pages3
JournalKidney international
Volume83
Issue number5
DOIs
StatePublished - May 2013

ASJC Scopus subject areas

  • Nephrology

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