Synthetic oleanane triterpenoids: Magic bullets or not?

Hanna E. Abboud

doi:10.1038/ki.2013.38

Synthetic oleanane triterpenoids: Magic bullets or not?

Hanna E. Abboud

Medicine

Research output: Contribution to journal › Comment/debate › peer-review

11 Scopus citations

Abstract

A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

Original language	English (US)
Pages (from-to)	785-787
Number of pages	3
Journal	Kidney international
Volume	83
Issue number	5
DOIs	https://doi.org/10.1038/ki.2013.38
State	Published - May 2013

ASJC Scopus subject areas

Nephrology

Access to Document

10.1038/ki.2013.38

Cite this

@article{e4e9062ff9104d50990ba6a2b1b5a3a2,

title = "Synthetic oleanane triterpenoids: Magic bullets or not?",

abstract = "A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.",

author = "Abboud, {Hanna E.}",

year = "2013",

month = may,

doi = "10.1038/ki.2013.38",

language = "English (US)",

volume = "83",

pages = "785--787",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Synthetic oleanane triterpenoids

T2 - Magic bullets or not?

AU - Abboud, Hanna E.

PY - 2013/5

Y1 - 2013/5

N2 - A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

AB - A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

UR - http://www.scopus.com/inward/record.url?scp=84877075423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877075423&partnerID=8YFLogxK

U2 - 10.1038/ki.2013.38

DO - 10.1038/ki.2013.38

M3 - Comment/debate

C2 - 23633050

AN - SCOPUS:84877075423

VL - 83

SP - 785

EP - 787

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 5

ER -

Synthetic oleanane triterpenoids: Magic bullets or not?

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this