Synthetic oleanane triterpenoids: Magic bullets or not?

Hanna E. Abboud

doi:10.1038/ki.2013.38

Synthetic oleanane triterpenoids: Magic bullets or not?

Hanna E. Abboud

Department of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

13 Scopus citations

Abstract

A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

Original language	English (US)
Pages (from-to)	785-787
Number of pages	3
Journal	Kidney international
Volume	83
Issue number	5
DOIs	https://doi.org/10.1038/ki.2013.38
State	Published - May 2013

ASJC Scopus subject areas

Nephrology

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title = "Synthetic oleanane triterpenoids: Magic bullets or not?",

abstract = "A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.",

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AB - A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.

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Synthetic oleanane triterpenoids: Magic bullets or not?

Abstract

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