Abstract
A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects.
Original language | English (US) |
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Pages (from-to) | 785-787 |
Number of pages | 3 |
Journal | Kidney international |
Volume | 83 |
Issue number | 5 |
DOIs |
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State | Published - May 2013 |
ASJC Scopus subject areas
- Nephrology