Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

Medicine and Dentistry

• Pleura Mesothelioma 100%
• PARP1 70%
• DNA Repair 40%
• Homologous Recombination 30%
• BRCA1 30%
• Survival 30%
• Lethality 20%
• Gene 20%
• Mesothelioma Cell Line 20%
• Olaparib 20%
• Niraparib 20%
• Cells 20%
• Mutant 20%
• Radiation Therapy 10%
• Chemotherapy 10%
• Malignant Neoplasm 10%
• Breast Cancer 10%
• Combination Therapy 10%
• Programmed Cell Death 10%
• Somatics 10%
• Ovarian Cancer 10%
• Genomic Instability 10%
• Therapeutic Procedure 10%
• Collapse 10%

Biochemistry, Genetics and Molecular Biology

• PARP1 70%
• BAP1 60%
• DNA Repair 40%
• Mutation 30%
• Homologous Recombination 30%
• BRCA1 30%
• Survival 30%
• Nested Gene 20%
• Synthetic Lethality 20%
• Mutant 20%
• Cell Death 10%
• BARD1 10%
• Genome Instability 10%
• Radiation 10%
• Collapse 10%