Synthesis of fused polycyclic β-carboline derivatives using Ugi-4CR followed by cascade cyclization

Vipin Kumar, Anjali Saxena, Ranjan Patra, Devalina Ray, Hong yu Li, Biswajit Saha

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Ugi-four component reaction (Ugi-4CR) is extremely attractive for diversity-oriented and step economical synthesis as evident from past applications. Here we report the synthesis of fused polycyclic β-carboline derivatives by sequential Pictet-Spengler’s and Ugi-4CR multi-component reaction followed by cascade cyclization. The post cyclisation of Ugi product provides conformationally stable heterocyclic molecule that is expected to be suitable for interaction with different biological targets. The methodology provides a simple and facile access to heterocycles embedded in polycyclic framework which otherwise seems difficult to synthesize by conventional methods. Graphical abstract: Synthesis of fused Polycyclic β-Carboline Derivatives Using Ugi-4CR Followed by Cascade Cyclization[Figure not available: see fulltext.]

Original languageEnglish (US)
Pages (from-to)951-957
Number of pages7
JournalMolecular Diversity
Issue number2
StatePublished - Apr 2023
Externally publishedYes


  • Cascade cyclization
  • Polycyclic β-carboline derivatives
  • Ugi-4CR

ASJC Scopus subject areas

  • Drug Discovery
  • Information Systems
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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