Synthesis of a bone-targeted bortezomib with in vivo anti-myeloma effects in mice

Hua Wang, Lifeng Xiao, Jianguo Tao, Venkat Srinivasan, Brendan F. Boyce, Frank H. Ebetino, Babatunde O. Oyajobi, Robert K. Boeckman, Lianping Xing

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Multiple myeloma (MM) is the most common cancer affecting the bone and bone marrow and remains incurable for most patients; novel therapies are therefore needed. Bortezomib (Btz) is an FDA-approved drug for the treatment of patients with MM. However, its severe side effects require a dose reduction or the potential discontinuation of treatment. To overcome this limitation, we conjugated Btz to a bisphosphonate (BP) residue lacking anti-osteoclastic activity using a novel chemical linker and generated a new bone-targeted Btz-based (BP-Btz) proteasome inhibitor. We demonstrated that BP-Btz, but not Btz, bound to bone slices and inhibited the growth of MM cells in vitro. In a mouse model of MM, BP-Btz more effectively reduced tumor burden and bone loss with less systemic side effects than Btz. Thus, BP-Btz may represent a novel therapeutic approach to treat patients with MM.

Original languageEnglish (US)
Article number154
JournalPharmaceutics
Volume10
Issue number3
DOIs
StatePublished - Sep 10 2018

Keywords

  • Bone targeting
  • Bortezomib
  • Drug delivery
  • Multiple myeloma
  • Velcade

ASJC Scopus subject areas

  • Pharmaceutical Science

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