Abstract
Several substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles were synthesized and evaluated for cytotoxic activity against estrogen-positive, estrogen-negative, and adriamycin-resistant human breast cancer cell lines. 4-[4′-(3,4-Dichlorophenoxy)-phenyl]-thiazol-2-yl ammonium iodide demonstrated potent activity against both estrogen-positive and negative breast cancer cell lines with low micromolar (μM) GI50 values. In addition, we have identified several 2-aminothiazoles that demonstrated selective potency for the adriamycin-resistant and estrogen-negative breast cancer cell lines. The results suggest that these 2-aminothiazoles represent lead compounds for evaluation in animal models of breast cancer.
Original language | English (US) |
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Pages (from-to) | 1029-1036 |
Number of pages | 8 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - Mar 1 2004 |
Externally published | Yes |
Keywords
- 2-Aminothiazoles
- Breast cancer
- Diaryl ethers
- Substituent effects
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry