Synthesis and chemical characterization of 2-methoxy-N¹⁰-substituted acridones needed to reverse vinblastine resistance in multidrug resistant (MDR) cancer cells

Chemistry

• Modulator 100%
• Verapamil 66%
• Glycoprotein 50%
• Cytotoxicity 50%
• Lipophilicity 33%
• Acridone 33%
• Resistance 33%
• Multiple Drug Resistance 33%
• Protein 16%
• 1H NMR Spectroscopy 16%
• Alkylation 16%
• Mass Spectrum Parameter 16%
• IC50 16%
• Iodide 16%
• IR Spectroscopy 16%
• Antiproliferative 16%
• Cyclization Reaction 16%
• Secondary Amine 16%
• 13C NMR Spectroscopy 16%
• UV/VIS Spectroscopy 16%
• Elemental Analysis 16%
• Reaction Yield 16%
• Tetrahydrofuran 16%
• Nucleophilic Substitution 16%
• Azidopine 16%
• Phase-Transfer Catalyst 16%
• Chlorobenzoic Acid 16%
• Polyphosphoric Acid 16%
• Potassium Hydroxide 16%
• Tetrabutylammonium Bromide 16%
• Concentration 16%
• Synthesis (Chemical) 16%
• Length 16%
• Correlation 16%
• Chemical Reaction Product 16%
• Carbon 16%
• Ullmann-Goldberg Amine Condensation 16%
• Hydrophobicity 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Effusion 66%
• Verapamil 66%
• Cytotoxicity 50%
• Vinblastine 50%
• P-Glycoprotein 50%
• Lipophilicity 33%
• Acridone Derivative 33%
• Amine 16%
• IC50 16%
• Propane 16%
• Element 16%
• Carrier Protein 16%
• Carbon 13 16%
• Malignant Neoplasm 16%
• Tritium 16%
• Drug 16%
• Iodide 16%
• Antiproliferative Activity 16%
• Acid 16%
• Tetrahydrofuran 16%
• Carbon 16%
• Hydrophobicity 16%
• Polyphosphate 16%
• Azidopine 16%
• Potassium Hydroxide 16%
• Tetrabutylammonium 16%
• Absence 16%