Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides

Nicholas A. Clanton, Shayne D. Hastings, Griffin B. Foultz, Julie A. Contreras, Samantha S. Yee, Hadi D. Arman, April L. Risinger, Doug E. Frantz

Research output: Contribution to journalArticlepeer-review

Abstract

Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development.

Original languageEnglish (US)
Pages (from-to)2534-2543
Number of pages10
JournalACS Medicinal Chemistry Letters
Volume11
Issue number12
DOIs
StatePublished - Dec 10 2020

Keywords

  • natural products
  • ovarian cancer
  • steroids
  • triple negative breast cancer

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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