Synthesis and Biological Evaluation of (-)-Laulimalide Analogues

Paul A. Wender, Sayee G. Hegde, Robert D. Hubbard, Lei Zhang, Susan L. Mooberry

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Equation presented. The syntheses of five laulimalide analogues are described, incorporating modifications at the C16-C 17-epoxide, the C20-alcohol, as well as the C 1-C3-enoate of the parent natural product. The resultant analogues are active in drug-sensitive HeLa and MDA-MB-435 cell lines. Significantly, like laulimalide, these analogues are poor substrates for the drug transport protein P-glycoprotein (Pgp) and are thus effective against Taxol-resistant cell lines.

Original languageEnglish (US)
Pages (from-to)3507-3509
Number of pages3
JournalOrganic Letters
Volume5
Issue number19
DOIs
StatePublished - Sep 18 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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