Equation presented. The syntheses of five laulimalide analogues are described, incorporating modifications at the C16-C 17-epoxide, the C20-alcohol, as well as the C 1-C3-enoate of the parent natural product. The resultant analogues are active in drug-sensitive HeLa and MDA-MB-435 cell lines. Significantly, like laulimalide, these analogues are poor substrates for the drug transport protein P-glycoprotein (Pgp) and are thus effective against Taxol-resistant cell lines.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry