Abstract
The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7α positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.
Original language | English (US) |
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Pages (from-to) | 1079-1089 |
Number of pages | 11 |
Journal | Steroids |
Volume | 67 |
Issue number | 13-14 |
DOIs | |
State | Published - Dec 1 2002 |
Externally published | Yes |
Keywords
- 2-Methoxyestradiol
- Antiangiogenesis
- Antimitotic activity
- Estrogens
- Steroids
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
- Pharmacology
- Clinical Biochemistry
- Organic Chemistry