Abstract
The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7α positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1079-1089 |
| Number of pages | 11 |
| Journal | Steroids |
| Volume | 67 |
| Issue number | 13-14 |
| DOIs | |
| State | Published - Dec 2002 |
| Externally published | Yes |
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Keywords
- 2-Methoxyestradiol
- Antiangiogenesis
- Antimitotic activity
- Estrogens
- Steroids
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Molecular Biology
Cite this
Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. / Rao, Pemmaraju N.; Cessac, James W.; Tinley, Tina L.; Mooberry, Susan L.
In: Steroids, Vol. 67, No. 13-14, 12.2002, p. 1079-1089.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs
AU - Rao, Pemmaraju N.
AU - Cessac, James W.
AU - Tinley, Tina L.
AU - Mooberry, Susan L
PY - 2002/12
Y1 - 2002/12
N2 - The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7α positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.
AB - The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7α positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.
KW - 2-Methoxyestradiol
KW - Antiangiogenesis
KW - Antimitotic activity
KW - Estrogens
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=0036890130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036890130&partnerID=8YFLogxK
U2 - 10.1016/S0039-128X(02)00066-1
DO - 10.1016/S0039-128X(02)00066-1
M3 - Article
C2 - 12441194
AN - SCOPUS:0036890130
VL - 67
SP - 1079
EP - 1089
JO - Steroids
JF - Steroids
SN - 0039-128X
IS - 13-14
ER -