Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs

Pemmaraju N. Rao, James W. Cessac, Tina L. Tinley, Susan L. Mooberry

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7α positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.

Original languageEnglish (US)
Pages (from-to)1079-1089
Number of pages11
Issue number13-14
StatePublished - Dec 2002


  • 2-Methoxyestradiol
  • Antiangiogenesis
  • Antimitotic activity
  • Estrogens
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry


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