Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs

Pemmaraju N. Rao, James W. Cessac, Tina L. Tinley, Susan L Mooberry

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7α positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.

Original languageEnglish (US)
Pages (from-to)1079-1089
Number of pages11
JournalSteroids
Volume67
Issue number13-14
DOIs
StatePublished - Dec 2002
Externally publishedYes

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Antimitotic Agents
Thermodynamic properties
Bioactivity
Substitution reactions
2-methoxyestradiol
C 15

Keywords

  • 2-Methoxyestradiol
  • Antiangiogenesis
  • Antimitotic activity
  • Estrogens
  • Steroids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Cite this

Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. / Rao, Pemmaraju N.; Cessac, James W.; Tinley, Tina L.; Mooberry, Susan L.

In: Steroids, Vol. 67, No. 13-14, 12.2002, p. 1079-1089.

Research output: Contribution to journalArticle

Rao, Pemmaraju N. ; Cessac, James W. ; Tinley, Tina L. ; Mooberry, Susan L. / Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. In: Steroids. 2002 ; Vol. 67, No. 13-14. pp. 1079-1089.
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