Synergy between Acute Intermittent Hypoxia and Task-Specific Training

Joseph F. Welch; Tommy W. Sutor; Alicia K. Vose; Raphael R. Perim; Emily J. Fox; Gordon S. Mitchell

doi:10.1249/JES.0000000000000222

Synergy between Acute Intermittent Hypoxia and Task-Specific Training

Joseph F. Welch, Tommy W. Sutor, Alicia K. Vose, Raphael R. Perim, Emily J. Fox, Gordon S. Mitchell

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working model of neural network and cellular elements to explain AIH-TST synergy. Our goal is to forecast experiments necessary to advance our understanding and optimize the neurotherapeutic potential of AIH-TST.

Original language	English (US)
Pages (from-to)	125-132
Number of pages	8
Journal	Exercise and Sport Sciences Reviews
Volume	48
Issue number	3
DOIs	https://doi.org/10.1249/JES.0000000000000222
State	Published - Jul 1 2020
Externally published	Yes

Keywords

acute intermittent hypoxia
exercise training
motor neuron
neuroplasticity
rehabilitation
spinal cord injury
spinal plasticity, phrenic

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000222

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title = "Synergy between Acute Intermittent Hypoxia and Task-Specific Training",

abstract = "Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working model of neural network and cellular elements to explain AIH-TST synergy. Our goal is to forecast experiments necessary to advance our understanding and optimize the neurotherapeutic potential of AIH-TST.",

keywords = "acute intermittent hypoxia, exercise training, motor neuron, neuroplasticity, rehabilitation, spinal cord injury, spinal plasticity, phrenic",

author = "Welch, {Joseph F.} and Sutor, {Tommy W.} and Vose, {Alicia K.} and Perim, {Raphael R.} and Fox, {Emily J.} and Mitchell, {Gordon S.}",

note = "Funding Information: This study was supported by the UF McKnight Brain Institute, the Craig H. Neilsen Foundation, DoD (SCIRP), NIH R01 HL147554, Brooks Rehabilitation, and the Brooks-PHHP Research Collaboration. Publisher Copyright: {\textcopyright} Lippincott Williams & Wilkins.",

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T1 - Synergy between Acute Intermittent Hypoxia and Task-Specific Training

AU - Welch, Joseph F.

AU - Sutor, Tommy W.

AU - Vose, Alicia K.

AU - Perim, Raphael R.

AU - Fox, Emily J.

AU - Mitchell, Gordon S.

N1 - Funding Information: This study was supported by the UF McKnight Brain Institute, the Craig H. Neilsen Foundation, DoD (SCIRP), NIH R01 HL147554, Brooks Rehabilitation, and the Brooks-PHHP Research Collaboration. Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2020/7/1

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N2 - Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working model of neural network and cellular elements to explain AIH-TST synergy. Our goal is to forecast experiments necessary to advance our understanding and optimize the neurotherapeutic potential of AIH-TST.

AB - Acute intermittent hypoxia (AIH) and task-specific training (TST) synergistically improve motor function after spinal cord injury; however, mechanisms underlying this synergistic relation are unknown. We propose a hypothetical working model of neural network and cellular elements to explain AIH-TST synergy. Our goal is to forecast experiments necessary to advance our understanding and optimize the neurotherapeutic potential of AIH-TST.

KW - acute intermittent hypoxia

KW - exercise training

KW - motor neuron

KW - neuroplasticity

KW - rehabilitation

KW - spinal cord injury

KW - spinal plasticity, phrenic

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Synergy between Acute Intermittent Hypoxia and Task-Specific Training

Abstract

Keywords

ASJC Scopus subject areas

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