Synergistic Effect of Cyclic Mechanical Strain and Activated Macrophage Cells on Nitinol Corrosion

Denes Marton, Eugene A Sprague

Research output: Contribution to journalArticle

Abstract

Several previous studies have documented that self-expanding (SE) Nitinol stents implanted in highly mobile peripheral arteries exhibit a fracture rate as high as 30%. The hypothesis of this study is that repetitive mechanical stresses interact synergistically with the atherosclerotic lesion environment to induce corrosive events that ultimately lead to nitinol stent material failure. Using a novel in vitro chamber, electro-polished nitinol coupons were subjected to cyclic defined stress regimens in the presence or absence of adherent acetylated lipoprotein-activated macrophage-like (THP-1) cells over a 5 day period. Nitinol surface corrosion was monitored in real time using open circuit potential (OCP) measurements. Changes in surface chemistry and topography were measured post-stress exposure using X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). The combination of defined bending in the presence of adherent activated macrophages resulted in a significant increase in nitinol surface corrosion as compared to nitinol subjected to either treatment or media exposure alone. Further, a deterioration of the protective oxide layer and an increase in the surface roughness were observed in nitinol specimens exposed to the combined influence of surface-adherent macrophages and repetitive loading. These results demonstrate a significant interaction between the biological and mechanical environment relative to nitinol corrosion potential and provide a basis for design of future studies to improve the long-term performance of peripheral nitinol stents.

Original languageEnglish (US)
Pages (from-to)216-224
Number of pages9
JournalCardiovascular Engineering and Technology
Volume1
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Stents
Corrosion
Macrophages
Lipoproteins
Surface topography
Surface chemistry
Deterioration
Atomic force microscopy
X ray photoelectron spectroscopy
Surface roughness
Oxides
Networks (circuits)
nitinol
Photoelectron Spectroscopy
Caustics
Mechanical Stress
Atomic Force Microscopy
Arteries

Keywords

  • Activated macrophages
  • Corrosion
  • Fatigue
  • Nitinol
  • Open circuit potential
  • X-ray photoelectron spectroscopy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine

Cite this

Synergistic Effect of Cyclic Mechanical Strain and Activated Macrophage Cells on Nitinol Corrosion. / Marton, Denes; Sprague, Eugene A.

In: Cardiovascular Engineering and Technology, Vol. 1, No. 3, 09.2010, p. 216-224.

Research output: Contribution to journalArticle

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