Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease

Matthew J. Dolan, Michael T. Wong, Russell L. Regnery, James H. Jorgensen, Maria Garcia, John Peters, Dennis Drehner

Research output: Contribution to journalArticle

268 Citations (Scopus)

Abstract

Objective: To describe a clinical syndrome of cat scratch disease caused by Rochalimaea henselae, including methods for isolation of the organism from tissue and for identification. Design: Case series. Setting: U.S. Air Force referral hospital infectious diseases clinic. Patients: Two previously healthy patients. Main Measurements and Results: Two immunocompetent patients who had handled cats developed unilateral upper-extremity adenitis associated with a distal papular lesion and fever. The adenitis and distal lesions persisted and progressively worsened. Cultures of the involved lymph nodes from both patients grew R. henselae, a recently described organism associated with bacillary angiomatosis and peliosis hepatis in human immunodeficiency virus-infected patients and with bacteremia in immunocompromised and immunocompetent hosts. The organism was characterized as oxidase negative and X-factor dependent and had a characteristic pattern in analysis of whole-cell fatty acids differing from Afipia felis, a bacterium that has been associated with cat scratch disease. The identity of the isolate was confirmed by analysis of whole-cell fatty acids using gas chromatography and by amplification of the citrate synthetase gene sequence and analysis of the polymerase chain reaction-amplified product. The organisms were broadly susceptible to a variety of antimicrobials by broth microdilution; however in-vitro resistance to first-generation cephalosporins correlated with clinical failure of therapy. Conclusion: Rochalimaea henselae can be a cause of cat scratch disease in immunocompetent patients.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalAnnals of Internal Medicine
Volume118
Issue number5
StatePublished - Mar 1 1993

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Bartonella henselae
Cat-Scratch Disease
Lymphadenitis
Afipia
Peliosis Hepatis
Fatty Acids
Bacillary Angiomatosis
Military Hospitals
Immunocompromised Host
Cephalosporins
Ligases
Bacteremia
Upper Extremity
Citric Acid
Gas Chromatography
Communicable Diseases
Sequence Analysis
Oxidoreductases
Cats
Fever

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dolan, M. J., Wong, M. T., Regnery, R. L., Jorgensen, J. H., Garcia, M., Peters, J., & Drehner, D. (1993). Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease. Annals of Internal Medicine, 118(5), 331-336.

Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease. / Dolan, Matthew J.; Wong, Michael T.; Regnery, Russell L.; Jorgensen, James H.; Garcia, Maria; Peters, John; Drehner, Dennis.

In: Annals of Internal Medicine, Vol. 118, No. 5, 01.03.1993, p. 331-336.

Research output: Contribution to journalArticle

Dolan, MJ, Wong, MT, Regnery, RL, Jorgensen, JH, Garcia, M, Peters, J & Drehner, D 1993, 'Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease', Annals of Internal Medicine, vol. 118, no. 5, pp. 331-336.
Dolan MJ, Wong MT, Regnery RL, Jorgensen JH, Garcia M, Peters J et al. Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease. Annals of Internal Medicine. 1993 Mar 1;118(5):331-336.
Dolan, Matthew J. ; Wong, Michael T. ; Regnery, Russell L. ; Jorgensen, James H. ; Garcia, Maria ; Peters, John ; Drehner, Dennis. / Syndrome of Rochalimaea henselae adenitis suggesting cat scratch disease. In: Annals of Internal Medicine. 1993 ; Vol. 118, No. 5. pp. 331-336.
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