Synchronized moving aperture radiation therapy (SMART): Superimposing tumor motion on IMRT MLC leaf sequences under realistic delivery conditions

Jun Xu, Nikos Papanikolaou, Chengyu Shi, Steve B. Jiang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Synchronized moving aperture radiation therapy (SMART) has been proposed to account for tumor motions during radiotherapy in prior work. The basic idea of SMART is to synchronize the moving radiation beam aperture formed by a dynamic multileaf collimator (DMLC) with the tumor motion induced by respiration. In this paper, a two-dimensional (2D) superimposing leaf sequencing method is presented for SMART. A leaf sequence optimization strategy was generated to assure the SMART delivery under realistic delivery conditions. The study of delivery performance using the Varian LINAC and the Millennium DMLC showed that clinical factors such as collimator angle, dose rate, initial phase and machine tolerance affect the delivery accuracy and efficiency. An in-house leaf sequencing software was developed to implement the 2D superimposing leaf sequencing method and optimize the motion-corrected leaf sequence under realistic clinical conditions. The analysis of dynamic log (Dynalog) files showed that optimization of the leaf sequence for various clinical factors can avoid beam hold-offs which break the synchronization of SMART and fail the SMART dose delivery. Through comparison between the simulated delivered fluence map and the planed fluence map, it was shown that the motion-corrected leaf sequence can greatly reduce the dose error.

Original languageEnglish (US)
Pages (from-to)4993-5007
Number of pages15
JournalPhysics in Medicine and Biology
Volume54
Issue number16
DOIs
StatePublished - 2009

Fingerprint

Radiotherapy
Neoplasms
Respiration
Software
Radiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Synchronized moving aperture radiation therapy (SMART) : Superimposing tumor motion on IMRT MLC leaf sequences under realistic delivery conditions. / Xu, Jun; Papanikolaou, Nikos; Shi, Chengyu; Jiang, Steve B.

In: Physics in Medicine and Biology, Vol. 54, No. 16, 2009, p. 4993-5007.

Research output: Contribution to journalArticle

@article{46be6617acea4b548d3a79ed35fc4c25,
title = "Synchronized moving aperture radiation therapy (SMART): Superimposing tumor motion on IMRT MLC leaf sequences under realistic delivery conditions",
abstract = "Synchronized moving aperture radiation therapy (SMART) has been proposed to account for tumor motions during radiotherapy in prior work. The basic idea of SMART is to synchronize the moving radiation beam aperture formed by a dynamic multileaf collimator (DMLC) with the tumor motion induced by respiration. In this paper, a two-dimensional (2D) superimposing leaf sequencing method is presented for SMART. A leaf sequence optimization strategy was generated to assure the SMART delivery under realistic delivery conditions. The study of delivery performance using the Varian LINAC and the Millennium DMLC showed that clinical factors such as collimator angle, dose rate, initial phase and machine tolerance affect the delivery accuracy and efficiency. An in-house leaf sequencing software was developed to implement the 2D superimposing leaf sequencing method and optimize the motion-corrected leaf sequence under realistic clinical conditions. The analysis of dynamic log (Dynalog) files showed that optimization of the leaf sequence for various clinical factors can avoid beam hold-offs which break the synchronization of SMART and fail the SMART dose delivery. Through comparison between the simulated delivered fluence map and the planed fluence map, it was shown that the motion-corrected leaf sequence can greatly reduce the dose error.",
author = "Jun Xu and Nikos Papanikolaou and Chengyu Shi and Jiang, {Steve B.}",
year = "2009",
doi = "10.1088/0031-9155/54/16/010",
language = "English (US)",
volume = "54",
pages = "4993--5007",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "16",

}

TY - JOUR

T1 - Synchronized moving aperture radiation therapy (SMART)

T2 - Superimposing tumor motion on IMRT MLC leaf sequences under realistic delivery conditions

AU - Xu, Jun

AU - Papanikolaou, Nikos

AU - Shi, Chengyu

AU - Jiang, Steve B.

PY - 2009

Y1 - 2009

N2 - Synchronized moving aperture radiation therapy (SMART) has been proposed to account for tumor motions during radiotherapy in prior work. The basic idea of SMART is to synchronize the moving radiation beam aperture formed by a dynamic multileaf collimator (DMLC) with the tumor motion induced by respiration. In this paper, a two-dimensional (2D) superimposing leaf sequencing method is presented for SMART. A leaf sequence optimization strategy was generated to assure the SMART delivery under realistic delivery conditions. The study of delivery performance using the Varian LINAC and the Millennium DMLC showed that clinical factors such as collimator angle, dose rate, initial phase and machine tolerance affect the delivery accuracy and efficiency. An in-house leaf sequencing software was developed to implement the 2D superimposing leaf sequencing method and optimize the motion-corrected leaf sequence under realistic clinical conditions. The analysis of dynamic log (Dynalog) files showed that optimization of the leaf sequence for various clinical factors can avoid beam hold-offs which break the synchronization of SMART and fail the SMART dose delivery. Through comparison between the simulated delivered fluence map and the planed fluence map, it was shown that the motion-corrected leaf sequence can greatly reduce the dose error.

AB - Synchronized moving aperture radiation therapy (SMART) has been proposed to account for tumor motions during radiotherapy in prior work. The basic idea of SMART is to synchronize the moving radiation beam aperture formed by a dynamic multileaf collimator (DMLC) with the tumor motion induced by respiration. In this paper, a two-dimensional (2D) superimposing leaf sequencing method is presented for SMART. A leaf sequence optimization strategy was generated to assure the SMART delivery under realistic delivery conditions. The study of delivery performance using the Varian LINAC and the Millennium DMLC showed that clinical factors such as collimator angle, dose rate, initial phase and machine tolerance affect the delivery accuracy and efficiency. An in-house leaf sequencing software was developed to implement the 2D superimposing leaf sequencing method and optimize the motion-corrected leaf sequence under realistic clinical conditions. The analysis of dynamic log (Dynalog) files showed that optimization of the leaf sequence for various clinical factors can avoid beam hold-offs which break the synchronization of SMART and fail the SMART dose delivery. Through comparison between the simulated delivered fluence map and the planed fluence map, it was shown that the motion-corrected leaf sequence can greatly reduce the dose error.

UR - http://www.scopus.com/inward/record.url?scp=70349784432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349784432&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/54/16/010

DO - 10.1088/0031-9155/54/16/010

M3 - Article

C2 - 19641237

AN - SCOPUS:70349784432

VL - 54

SP - 4993

EP - 5007

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 16

ER -