Synaptic reorganization in the hippocampus induced by abnormal functional activity

Thomas Sutula, He Xiao-Xian, Jose E Cavazos, Grayson Scott

Research output: Contribution to journalArticle

742 Citations (Scopus)

Abstract

Abnormal functional activity induces long-lasting physiological alterations in neural pathways that may play a role in the development of epilepsy. The cellular mechanisms of these alterations are not well understood. One hypothesis is that abnormal activity causes structural reorganization of neural pathways and promotes epileptogenesis. This report provides morphological evidence that synchronous perforant path activation and kindling of limbic pathways induce axonal growth and synaptic reorganization in the hippocampus, in the absence of overt morphological damage. The results show a previously unrecognized anatomic plasticity associated with synchronous activity and development of epileptic seizures in neural pathways.

Original languageEnglish (US)
Pages (from-to)1147-1150
Number of pages4
JournalScience
Volume239
Issue number4844
StatePublished - 1988
Externally publishedYes

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Neural Pathways
Hippocampus
Epilepsy
Perforant Pathway
Growth

ASJC Scopus subject areas

  • General

Cite this

Sutula, T., Xiao-Xian, H., Cavazos, J. E., & Scott, G. (1988). Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science, 239(4844), 1147-1150.

Synaptic reorganization in the hippocampus induced by abnormal functional activity. / Sutula, Thomas; Xiao-Xian, He; Cavazos, Jose E; Scott, Grayson.

In: Science, Vol. 239, No. 4844, 1988, p. 1147-1150.

Research output: Contribution to journalArticle

Sutula, T, Xiao-Xian, H, Cavazos, JE & Scott, G 1988, 'Synaptic reorganization in the hippocampus induced by abnormal functional activity', Science, vol. 239, no. 4844, pp. 1147-1150.
Sutula, Thomas ; Xiao-Xian, He ; Cavazos, Jose E ; Scott, Grayson. / Synaptic reorganization in the hippocampus induced by abnormal functional activity. In: Science. 1988 ; Vol. 239, No. 4844. pp. 1147-1150.
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