Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 16-20 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 65 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
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Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. / Luesch, Hendrik; Yoshida, Wesley Y.; Moore, Richard E.; Paul, Valerie J.; Mooberry, Susan L; Corbett, Thomas H.
In: Journal of Natural Products, Vol. 65, No. 1, 2002, p. 16-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452
AU - Luesch, Hendrik
AU - Yoshida, Wesley Y.
AU - Moore, Richard E.
AU - Paul, Valerie J.
AU - Mooberry, Susan L
AU - Corbett, Thomas H.
PY - 2002
Y1 - 2002
N2 - Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.
AB - Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=0036165655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036165655&partnerID=8YFLogxK
U2 - 10.1021/np010317s
DO - 10.1021/np010317s
M3 - Article
C2 - 11809057
AN - SCOPUS:0036165655
VL - 65
SP - 16
EP - 20
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 1
ER -