Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

Hendrik Luesch, Wesley Y. Yoshida, Richard E. Moore, Valerie J. Paul, Susan L Mooberry, Thomas H. Corbett

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalJournal of Natural Products
Volume65
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

dolastatin 10
Symploca
Cyanobacteria
Cytotoxicity
cytotoxicity
Tumors
phenyllactic acid
Tumor Cell Line
Microtubules
microtubules
Inhibitory Concentration 50
inhibitory concentration 50
Cells
cell lines
neoplasms
extracts
Neoplasms
symplostatin 3
In Vitro Techniques
symplostatin 1

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. / Luesch, Hendrik; Yoshida, Wesley Y.; Moore, Richard E.; Paul, Valerie J.; Mooberry, Susan L; Corbett, Thomas H.

In: Journal of Natural Products, Vol. 65, No. 1, 2002, p. 16-20.

Research output: Contribution to journalArticle

Luesch, Hendrik ; Yoshida, Wesley Y. ; Moore, Richard E. ; Paul, Valerie J. ; Mooberry, Susan L ; Corbett, Thomas H. / Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. In: Journal of Natural Products. 2002 ; Vol. 65, No. 1. pp. 16-20.
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abstract = "Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.",
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AU - Mooberry, Susan L

AU - Corbett, Thomas H.

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AB - Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.

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