Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

Hendrik Luesch; Wesley Y. Yoshida; Richard E. Moore; Valerie J. Paul; Susan L. Mooberry; Thomas H. Corbett

doi:10.1021/np010317s

Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

Hendrik Luesch, Wesley Y. Yoshida, Richard E. Moore, Valerie J. Paul, Susan L. Mooberry, Thomas H. Corbett

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC₅₀ values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.

Original language	English (US)
Pages (from-to)	16-20
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	1
DOIs	https://doi.org/10.1021/np010317s
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010317s

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AU - Mooberry, Susan L.

AU - Corbett, Thomas H.

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