Abstract
Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 16-20 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 65 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 12 2002 |
| Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Luesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J., Mooberry, S. L., & Corbett, T. H. (2002). Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452. Journal of Natural Products, 65(1), 16-20. https://doi.org/10.1021/np010317s