Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

Hendrik Luesch; Wesley Y. Yoshida; Richard E. Moore; Valerie J. Paul; Susan L. Mooberry; Thomas H. Corbett

doi:10.1021/np010317s

Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

Hendrik Luesch, Wesley Y. Yoshida, Richard E. Moore, Valerie J. Paul, Susan L. Mooberry, Thomas H. Corbett

Pharmacology

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC₅₀ values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.

Original language	English (US)
Pages (from-to)	16-20
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	1
DOIs	https://doi.org/10.1021/np010317s
State	Published - 2002

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010317s

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abstract = "Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.",

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AU - Mooberry, Susan L.

AU - Corbett, Thomas H.

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AB - Symplostatin 3 (1), a new analogue of dolastatin 10 (2), has been isolated from a tumor selective extract of a Hawaiian variety of the marine cyanobacterium Symploca sp. VP452. Compound 1 differs from 2 only in the C-terminal unit; the dolaphenine unit is substituted by a 3-phenyllactic acid residue. Symplostatin 3 (1) possesses IC50 values for in vitro cytotoxicity toward human tumor cell lines ranging from 3.9 to 10.3 nM. It disrupts microtubules, but at a higher concentration than 2, correlating with the weaker in vitro cytotoxicity.

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Symplostatin 3, a new dolastatin 10 analogue from the marine cyanobacterium Symploca sp. VP452

Abstract

ASJC Scopus subject areas

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