Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

George G. Harrigan, Hendrik Luesch, Wesley Y. Yoshida, Richard E. Moore, Dale G. Nagle, Valerie J. Paul, Susan L. Mooberry, Thomas H. Corbett, Fred A. Valeriote

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

Original languageEnglish (US)
Pages (from-to)1075-1077
Number of pages3
JournalJournal of Natural Products
Volume61
Issue number9
DOIs
StatePublished - Sep 1998
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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