Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

George G. Harrigan; Hendrik Luesch; Wesley Y. Yoshida; Richard E. Moore; Dale G. Nagle; Valerie J. Paul; Susan L. Mooberry; Thomas H. Corbett; Fred A. Valeriote

doi:10.1021/np980321c

Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

George G. Harrigan, Hendrik Luesch, Wesley Y. Yoshida, Richard E. Moore, Dale G. Nagle, Valerie J. Paul, Susan L. Mooberry, Thomas H. Corbett, Fred A. Valeriote

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

Original language	English (US)
Pages (from-to)	1075-1077
Number of pages	3
Journal	Journal of Natural Products
Volume	61
Issue number	9
DOIs	https://doi.org/10.1021/np980321c
State	Published - Sep 1998
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np980321c

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title = "Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides",

abstract = "A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.",

author = "Harrigan, {George G.} and Hendrik Luesch and Yoshida, {Wesley Y.} and Moore, {Richard E.} and Nagle, {Dale G.} and Paul, {Valerie J.} and Mooberry, {Susan L.} and Corbett, {Thomas H.} and Valeriote, {Fred A.}",

year = "1998",

month = sep,

doi = "10.1021/np980321c",

language = "English (US)",

volume = "61",

pages = "1075--1077",

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T2 - A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

AU - Harrigan, George G.

AU - Luesch, Hendrik

AU - Yoshida, Wesley Y.

AU - Moore, Richard E.

AU - Nagle, Dale G.

AU - Paul, Valerie J.

AU - Mooberry, Susan L.

AU - Corbett, Thomas H.

AU - Valeriote, Fred A.

PY - 1998/9

Y1 - 1998/9

N2 - A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

AB - A new solid tumor selective cytotoxic analogue of dolastatin 10 (1) has been isolated from the marine cyanobacterium Symploca hydnoides, collected near Guam. This metabolite has been assigned the trivial name symplostatin 1 (2). This discovery supports the proposal that many compounds isolated from the seahare Dolabella auricularia, the original source of the dolastatins, are of dietary origin.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Symplostatin 1: A dolastatin 10 analogue from the marine cyanobacterium Symploca hydnoides

Abstract

ASJC Scopus subject areas

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