Sympathetic Ophthalmia - An Overview

Mamta Agarwal, Aleksandra Radosavljevic, Mudit Tyagi, Francesco Pichi, Aisha A. Al Dhanhani, Aditi Agarwal, Emmett T. Cunningham

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Introduction: Sympathetic ophthalmia (SO) is rare, bilateral granulomatous panuveitis that typically occurs following penetrating or perforating ocular trauma or surgery. This review aims to provide an update on the etiopathogenesis, clinical presentations, diagnosis and treatment of SO. Methods: Reports cited in MEDLINE database, that analyzed SO in at least 5 patients, published prior to December 1st, 2021 were included. Results: Initially, SO was associated with penetrating ocular trauma, however, various studies reported an increased incidence of SO after surgical procedures including vitreoretinal surgeries. Multimodal imaging including fluorescein and indocyanine green angiography, optical coherence tomography (OCT) and OCT angiography have added further insights into the understanding of SO. While pulse dose corticosteroids & immunosuppressive drugs are still the treatment of choice, TNF-α blockers & other biologic drugs represent new promising agents. Conclusion: There is a growing pool of evidence in understanding the pathogenesis of SO. Novel treatment options have provided better prognosis for this potentially blinding condition.

Original languageEnglish (US)
Pages (from-to)793-809
Number of pages17
JournalOcular Immunology and Inflammation
Volume31
Issue number4
DOIs
StatePublished - 2023
Externally publishedYes

Keywords

  • Immunosuppression
  • ocular trauma
  • panuveitis
  • sympathetic ophthalmia
  • vitreoretinal surgery

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

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