Abstract
Effects of water deprivation on rhythmic bursting of sympathetic nerve activity (SNA) were investigated in anesthetized, bilaterally vagotomized, euhydrated (control) and 48-h water-deprived (WD) rats (n = 8/group). Control and WD rats had similar baseline values of mean arterial pressure, heart rate, end-tidal CO2, and central respiratory drive. Although integrated splanchnic SNA (sSNA) was greater in WD rats than controls (P < 0.01), analysis of respiratory rhythmic bursting of sSNA revealed that inspiratory rhythmic burst amplitude was actually smaller (P < 0.005) in WD rats (+68 ± 6%) than controls (+208 ± 20%), and amplitudes of the early expiratory (postinspiratory) trough and late expiratory burst of sSNA were not different between groups. Further analysis revealed that water deprivation had no effect on either the amplitude or periodicity of the cardiac rhythmic oscillation of sSNA. Collectively, these data indicate that the increase of sSNA produced by water deprivation is not attributable to either increased respiratory or cardiac rhythmic burst discharge. Thus the sympathetic network response to acute water deprivation appears to differ from that of chronic sympathoexcitation in neurogenic forms of arterial hypertension, where increased respiratory rhythmic bursting of SNA and baroreflex adaptations have been reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1689-1696 |
| Number of pages | 8 |
| Journal | Journal of Applied Physiology |
| Volume | 114 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jun 15 2013 |
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Keywords
- Hypertension
- Paraventricular nucleus
- Respiratory network
- Rostral ventrolateral medulla
- Sympathetic nerve activity
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Sympathetic network drive during water deprivation does not increase respiratory or cardiac rhythmic sympathetic nerve activity. / Holbein, Walter W.; Toney, Glenn M.
In: Journal of Applied Physiology, Vol. 114, No. 12, 15.06.2013, p. 1689-1696.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sympathetic network drive during water deprivation does not increase respiratory or cardiac rhythmic sympathetic nerve activity
AU - Holbein, Walter W.
AU - Toney, Glenn M
PY - 2013/6/15
Y1 - 2013/6/15
N2 - Effects of water deprivation on rhythmic bursting of sympathetic nerve activity (SNA) were investigated in anesthetized, bilaterally vagotomized, euhydrated (control) and 48-h water-deprived (WD) rats (n = 8/group). Control and WD rats had similar baseline values of mean arterial pressure, heart rate, end-tidal CO2, and central respiratory drive. Although integrated splanchnic SNA (sSNA) was greater in WD rats than controls (P < 0.01), analysis of respiratory rhythmic bursting of sSNA revealed that inspiratory rhythmic burst amplitude was actually smaller (P < 0.005) in WD rats (+68 ± 6%) than controls (+208 ± 20%), and amplitudes of the early expiratory (postinspiratory) trough and late expiratory burst of sSNA were not different between groups. Further analysis revealed that water deprivation had no effect on either the amplitude or periodicity of the cardiac rhythmic oscillation of sSNA. Collectively, these data indicate that the increase of sSNA produced by water deprivation is not attributable to either increased respiratory or cardiac rhythmic burst discharge. Thus the sympathetic network response to acute water deprivation appears to differ from that of chronic sympathoexcitation in neurogenic forms of arterial hypertension, where increased respiratory rhythmic bursting of SNA and baroreflex adaptations have been reported.
AB - Effects of water deprivation on rhythmic bursting of sympathetic nerve activity (SNA) were investigated in anesthetized, bilaterally vagotomized, euhydrated (control) and 48-h water-deprived (WD) rats (n = 8/group). Control and WD rats had similar baseline values of mean arterial pressure, heart rate, end-tidal CO2, and central respiratory drive. Although integrated splanchnic SNA (sSNA) was greater in WD rats than controls (P < 0.01), analysis of respiratory rhythmic bursting of sSNA revealed that inspiratory rhythmic burst amplitude was actually smaller (P < 0.005) in WD rats (+68 ± 6%) than controls (+208 ± 20%), and amplitudes of the early expiratory (postinspiratory) trough and late expiratory burst of sSNA were not different between groups. Further analysis revealed that water deprivation had no effect on either the amplitude or periodicity of the cardiac rhythmic oscillation of sSNA. Collectively, these data indicate that the increase of sSNA produced by water deprivation is not attributable to either increased respiratory or cardiac rhythmic burst discharge. Thus the sympathetic network response to acute water deprivation appears to differ from that of chronic sympathoexcitation in neurogenic forms of arterial hypertension, where increased respiratory rhythmic bursting of SNA and baroreflex adaptations have been reported.
KW - Hypertension
KW - Paraventricular nucleus
KW - Respiratory network
KW - Rostral ventrolateral medulla
KW - Sympathetic nerve activity
UR - http://www.scopus.com/inward/record.url?scp=84879236376&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879236376&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00078.2013
DO - 10.1152/japplphysiol.00078.2013
M3 - Article
C2 - 23580603
AN - SCOPUS:84879236376
VL - 114
SP - 1689
EP - 1696
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 0161-7567
IS - 12
ER -