Sympathetic network drive during water deprivation does not increase respiratory or cardiac rhythmic sympathetic nerve activity

Walter W. Holbein, Glenn M Toney

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Effects of water deprivation on rhythmic bursting of sympathetic nerve activity (SNA) were investigated in anesthetized, bilaterally vagotomized, euhydrated (control) and 48-h water-deprived (WD) rats (n = 8/group). Control and WD rats had similar baseline values of mean arterial pressure, heart rate, end-tidal CO2, and central respiratory drive. Although integrated splanchnic SNA (sSNA) was greater in WD rats than controls (P < 0.01), analysis of respiratory rhythmic bursting of sSNA revealed that inspiratory rhythmic burst amplitude was actually smaller (P < 0.005) in WD rats (+68 ± 6%) than controls (+208 ± 20%), and amplitudes of the early expiratory (postinspiratory) trough and late expiratory burst of sSNA were not different between groups. Further analysis revealed that water deprivation had no effect on either the amplitude or periodicity of the cardiac rhythmic oscillation of sSNA. Collectively, these data indicate that the increase of sSNA produced by water deprivation is not attributable to either increased respiratory or cardiac rhythmic burst discharge. Thus the sympathetic network response to acute water deprivation appears to differ from that of chronic sympathoexcitation in neurogenic forms of arterial hypertension, where increased respiratory rhythmic bursting of SNA and baroreflex adaptations have been reported.

Original languageEnglish (US)
Pages (from-to)1689-1696
Number of pages8
JournalJournal of Applied Physiology
Volume114
Issue number12
DOIs
StatePublished - Jun 15 2013

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Water Deprivation
Viscera
Water
Baroreflex
Periodicity
Drive
Arterial Pressure
Heart Rate
Hypertension

Keywords

  • Hypertension
  • Paraventricular nucleus
  • Respiratory network
  • Rostral ventrolateral medulla
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Sympathetic network drive during water deprivation does not increase respiratory or cardiac rhythmic sympathetic nerve activity. / Holbein, Walter W.; Toney, Glenn M.

In: Journal of Applied Physiology, Vol. 114, No. 12, 15.06.2013, p. 1689-1696.

Research output: Contribution to journalArticle

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