Abstract
Background: Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition. Objective: To assess verbal fluency in patients with SC. Patients and methods: We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school. Results: The scores of the control group on the SVF and PVF tests were 26.3±5.7 and 18.0±6.4 whereas the SC patients scored 25.1±6.9 and 12.5±8.2. PVF was significantly decreased in the SC group (p<0.01). Conclusion: SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 3 |
| Journal | Parkinsonism and Related Disorders |
| Volume | 12 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 2006 |
| Externally published | Yes |
Keywords
- Antibasal gangila antibodies
- Chorea
- Fronto-striatal circuits
- Sydenham's chorea
- Verbal fluency
ASJC Scopus subject areas
- Neurology
- Geriatrics and Gerontology
- Clinical Neurology
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