Sydenham's chorea is associated with decreased verbal fluency

Mauro César Quintão Silva Cunningham; Débora Palma Maia; Antonio Lúcio Teixeira; Francisco Cardoso

doi:10.1016/j.parkreldis.2005.11.003

Sydenham's chorea is associated with decreased verbal fluency

Mauro César Quintão Silva Cunningham, Débora Palma Maia, Antonio Lúcio Teixeira, Francisco Cardoso

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition. Objective: To assess verbal fluency in patients with SC. Patients and methods: We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school. Results: The scores of the control group on the SVF and PVF tests were 26.3±5.7 and 18.0±6.4 whereas the SC patients scored 25.1±6.9 and 12.5±8.2. PVF was significantly decreased in the SC group (p<0.01). Conclusion: SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.

Original language	English (US)
Pages (from-to)	165-167
Number of pages	3
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.parkreldis.2005.11.003
State	Published - Apr 2006
Externally published	Yes

Keywords

Antibasal gangila antibodies
Chorea
Fronto-striatal circuits
Sydenham's chorea
Verbal fluency

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2005.11.003

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title = "Sydenham's chorea is associated with decreased verbal fluency",

abstract = "Background: Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition. Objective: To assess verbal fluency in patients with SC. Patients and methods: We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school. Results: The scores of the control group on the SVF and PVF tests were 26.3±5.7 and 18.0±6.4 whereas the SC patients scored 25.1±6.9 and 12.5±8.2. PVF was significantly decreased in the SC group (p<0.01). Conclusion: SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.",

keywords = "Antibasal gangila antibodies, Chorea, Fronto-striatal circuits, Sydenham's chorea, Verbal fluency",

author = "Cunningham, {Mauro C{\'e}sar Quint{\~a}o Silva} and Maia, {D{\'e}bora Palma} and Teixeira, {Antonio L{\'u}cio} and Francisco Cardoso",

year = "2006",

month = apr,

doi = "10.1016/j.parkreldis.2005.11.003",

language = "English (US)",

volume = "12",

pages = "165--167",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

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AU - Cunningham, Mauro César Quintão Silva

AU - Maia, Débora Palma

AU - Teixeira, Antonio Lúcio

AU - Cardoso, Francisco

PY - 2006/4

Y1 - 2006/4

N2 - Background: Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition. Objective: To assess verbal fluency in patients with SC. Patients and methods: We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school. Results: The scores of the control group on the SVF and PVF tests were 26.3±5.7 and 18.0±6.4 whereas the SC patients scored 25.1±6.9 and 12.5±8.2. PVF was significantly decreased in the SC group (p<0.01). Conclusion: SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.

AB - Background: Sydenham's chorea (SC) is a disorder associated with rheumatic fever and related to Streptococcus-induced immune reaction cross-reactive with basal ganglia antigens. Obsessive-compulsive disorder and other behavioral abnormalities have been described in SC. There are scarce data of cognitive function in this condition. Objective: To assess verbal fluency in patients with SC. Patients and methods: We have compared the semantic (SVF) and phonemic verbal fluency (PVF) of 20 subjects with SC and 40 controls matched by age, gender and years of school. Results: The scores of the control group on the SVF and PVF tests were 26.3±5.7 and 18.0±6.4 whereas the SC patients scored 25.1±6.9 and 12.5±8.2. PVF was significantly decreased in the SC group (p<0.01). Conclusion: SC is associated with reduction of PVF. This finding may reflect disruption of the dorsolateral prefrontal-striatal circuit caused by the auto-immune process characteristic of SC.

KW - Antibasal gangila antibodies

KW - Chorea

KW - Fronto-striatal circuits

KW - Sydenham's chorea

KW - Verbal fluency

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Sydenham's chorea is associated with decreased verbal fluency

Abstract

Keywords

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