Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents

James H. Jorgensen, Gary V. Doern, Clyde Thornsberry, David A. Preston, Judith S. Redding, Louise A. Maher, Tracey Tubert

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

One hundred and six isolates of Haemophilus influenzae from a national antimicrobial surveillance study demonstrated resistance to two or more of 10 primary antimicrobial agents by mechanisms other than or in addition to beta-lactamase. Of particular note were strains multiply resistant to ampicillin (by beta-lactamase production), chloramphenicol, trimethoprim/sulfamethoxazole, and tetracycline in various combinations. All of the aforementioned strains were shown to be highly susceptible to amoxicillin/clavulanate, the second generation cephalosporins cefuroxime and cefonicid, and the third generation cephalosporins cefotaxime, ceftizoxime, ceftriaxone, ceftazidime, moxalactam, and cefixime. However, 68 strains that demonstrated resistance or marginal susceptibility (MIC ≥ 2 μg/ml) to ampicillin by mechanisms other than beta-lactamase, also demonstrated reduced susceptibility to amoxicillin/clavulanate (MICs up to 8 μg/ml) and the second generation cephalosporins (MICs up to 32 μg/ml). While the latter strains were susceptible to the third generation cephalosporins, MICs were often 10-fold higher than MICs of ampicillin susceptible isolates or of beta-lactamase producing isolates. All of the multiply antimicrobial-resistant strains were highly susceptible (MIC ≤ 0.25 μg/ml) to the two quinolones ciprofloxacin and pefloxacin.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume9
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Haemophilus influenzae
Cephalosporins
beta-Lactamases
Anti-Infective Agents
Ampicillin
Clavulanic Acid
Amoxicillin
Cefonicid
Ceftizoxime
Pefloxacin
Cefixime
Moxalactam
Cefuroxime
Ceftazidime
Cefotaxime
Ceftriaxone
Quinolones
Sulfamethoxazole Drug Combination Trimethoprim
Chloramphenicol
Ciprofloxacin

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Jorgensen, J. H., Doern, G. V., Thornsberry, C., Preston, D. A., Redding, J. S., Maher, L. A., & Tubert, T. (1988). Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents. Diagnostic Microbiology and Infectious Disease, 9(1), 27-32. https://doi.org/10.1016/0732-8893(88)90057-0

Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents. / Jorgensen, James H.; Doern, Gary V.; Thornsberry, Clyde; Preston, David A.; Redding, Judith S.; Maher, Louise A.; Tubert, Tracey.

In: Diagnostic Microbiology and Infectious Disease, Vol. 9, No. 1, 1988, p. 27-32.

Research output: Contribution to journalArticle

Jorgensen, JH, Doern, GV, Thornsberry, C, Preston, DA, Redding, JS, Maher, LA & Tubert, T 1988, 'Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents', Diagnostic Microbiology and Infectious Disease, vol. 9, no. 1, pp. 27-32. https://doi.org/10.1016/0732-8893(88)90057-0
Jorgensen, James H. ; Doern, Gary V. ; Thornsberry, Clyde ; Preston, David A. ; Redding, Judith S. ; Maher, Louise A. ; Tubert, Tracey. / Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents. In: Diagnostic Microbiology and Infectious Disease. 1988 ; Vol. 9, No. 1. pp. 27-32.
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