TY - JOUR
T1 - Susceptibility of multiply resistant Haemophilus influenzae to newer antimicrobial agents
AU - Jorgensen, James H.
AU - Doern, Gary V.
AU - Thornsberry, Clyde
AU - Preston, David A.
AU - Redding, Judith S.
AU - Maher, Louise A.
AU - Tubert, Tracey
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1988/1
Y1 - 1988/1
N2 - One hundred and six isolates of Haemophilus influenzae from a national antimicrobial surveillance study demonstrated resistance to two or more of 10 primary antimicrobial agents by mechanisms other than or in addition to beta-lactamase. Of particular note were strains multiply resistant to ampicillin (by beta-lactamase production), chloramphenicol, trimethoprim/sulfamethoxazole, and tetracycline in various combinations. All of the aforementioned strains were shown to be highly susceptible to amoxicillin/clavulanate, the second generation cephalosporins cefuroxime and cefonicid, and the third generation cephalosporins cefotaxime, ceftizoxime, ceftriaxone, ceftazidime, moxalactam, and cefixime. However, 68 strains that demonstrated resistance or marginal susceptibility (MIC ≥ 2 μg/ml) to ampicillin by mechanisms other than beta-lactamase, also demonstrated reduced susceptibility to amoxicillin/clavulanate (MICs up to 8 μg/ml) and the second generation cephalosporins (MICs up to 32 μg/ml). While the latter strains were susceptible to the third generation cephalosporins, MICs were often 10-fold higher than MICs of ampicillin susceptible isolates or of beta-lactamase producing isolates. All of the multiply antimicrobial-resistant strains were highly susceptible (MIC ≤ 0.25 μg/ml) to the two quinolones ciprofloxacin and pefloxacin.
AB - One hundred and six isolates of Haemophilus influenzae from a national antimicrobial surveillance study demonstrated resistance to two or more of 10 primary antimicrobial agents by mechanisms other than or in addition to beta-lactamase. Of particular note were strains multiply resistant to ampicillin (by beta-lactamase production), chloramphenicol, trimethoprim/sulfamethoxazole, and tetracycline in various combinations. All of the aforementioned strains were shown to be highly susceptible to amoxicillin/clavulanate, the second generation cephalosporins cefuroxime and cefonicid, and the third generation cephalosporins cefotaxime, ceftizoxime, ceftriaxone, ceftazidime, moxalactam, and cefixime. However, 68 strains that demonstrated resistance or marginal susceptibility (MIC ≥ 2 μg/ml) to ampicillin by mechanisms other than beta-lactamase, also demonstrated reduced susceptibility to amoxicillin/clavulanate (MICs up to 8 μg/ml) and the second generation cephalosporins (MICs up to 32 μg/ml). While the latter strains were susceptible to the third generation cephalosporins, MICs were often 10-fold higher than MICs of ampicillin susceptible isolates or of beta-lactamase producing isolates. All of the multiply antimicrobial-resistant strains were highly susceptible (MIC ≤ 0.25 μg/ml) to the two quinolones ciprofloxacin and pefloxacin.
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U2 - 10.1016/0732-8893(88)90057-0
DO - 10.1016/0732-8893(88)90057-0
M3 - Article
C2 - 3259490
AN - SCOPUS:0023927062
VL - 9
SP - 27
EP - 32
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
SN - 0732-8893
IS - 1
ER -