Susceptibility locus for Alzheimer's disease on chromosome 10

A. Myers, P. Holmans, H. Marshall, J. Kwon, D. Meyer, D. Ramic, S. Shears, J. Booth, F. W. DeVrieze, R. Crook, M. Hamshere, R. Abraham, N. Tunstall, F. Rice, S. Carty, S. Lillystone, P. Kehoe, V. Rudrasingham, L. Jones, S. LovestoneJ. Perez-Tur, J. Williams, M. J. Owen, J. Hardy, A. M. Goate

    Research output: Contribution to journalArticlepeer-review

    337 Scopus citations

    Abstract

    The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.

    Original languageEnglish (US)
    Pages (from-to)2304-2305
    Number of pages2
    JournalScience
    Volume290
    Issue number5500
    DOIs
    StatePublished - Dec 22 2000

    ASJC Scopus subject areas

    • General

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