Survival of cryopreservation and thawing with all blastomeres intact identifies multicell embryos with superior frozen embryo transfer outcome

William N. Burns, Tracy W. Gaudet, Maxine B. Martin, Y. Ramiro Leal, Heather Schoen, Carlton A. Eddy, Robert S. Schenken

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Objective: To assess the impact of survival of cryopreservation and thawing with all blastomeres intact on the outcome of multicell frozen ET.Design: Retrospective study.Setting: Academic assisted reproductive technology program.Patient(s): One hundred sixteen exclusively multicell frozen ETs in 78 patients.Intervention(s): Frozen ET.Main Outcome Measure(s): Relation of embryonic blastomere survival to the outcome of frozen ET (i.e., pregnancy).Result(s): When at least one embryo survived with all blastomeres intact, the total pregnancy rate (biochemical, clinical, or delivered) was 37.7%, the clinical pregnancy rate was 24.6%, and the delivered pregnancy rate was 18.8%. When no embryo survived with all blastomeres intact, the corresponding rates were 10.6%, 8.5%, and 6.4%. The differences in the total pregnancy rate and the clinical pregnancy rate were statistically significant. The delivered pregnancy rates approached statistical significance.Conclusion(s): Multicell embryonic survival of cryopreservation and thawing with all blastomeres intact identifies embryos with superior developmental potential. Copyright (C) 1999 American Society for Reproductive Medicine.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalFertility and Sterility
Volume72
Issue number3
DOIs
StatePublished - Sep 1 1999

Keywords

  • Blastomere survival
  • Cryopreservation
  • Embryo
  • Frozen embryo transfer
  • Pregnancy rate

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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