Survival experience of 789 children with the acquired immunodeficiency syndrome

Barbara J. Turner, Mark Denison, Stephen C. Eppes, Robert Houchens, Thomas Fanning, Leona E. Markson

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52 Scopus citations

Abstract

To define predictors of survival we studied longitudinal histories of 789 New York State Medicaid-enrolled children diagnosed with acquired immunodeficiency syndrome (AIDS) from 1983 to 1989 and followed through 1990. Median survival times for 3 severity groups of AIDS-defining conditions were 66, 48 and 9 months. In a proportional hazards model, the relative risk of death for the most vs. least severe group was 3.33 (95% confidence interval, 2.53, 4.37) and the relative risk for children <6 months old at diagnosis vs. older children was 1.81 (95% confidence interval, 1.41, 2.34). We increased our ability to predict death by using a 4-category severity index that assesses both the AIDS-defining diagnosis and clinical complications within 3 months of diagnosis (relative risk, 5.27; 95% confidence interval, 3.16, 8.78 for most vs. least severe). These analyses offer new clinical severity measures and reveal that, regardless of the AIDS-defining diagnosis, children with AIDS who are <6 months old have a poor prognosis.

Original languageEnglish (US)
Pages (from-to)310-320
Number of pages11
JournalPediatric Infectious Disease Journal
Volume12
Issue number4
DOIs
StatePublished - Apr 1993

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Keywords

  • Medicaid
  • Severity of illness
  • acquired immunodeficiency syndrome
  • child
  • infant
  • medical assistance
  • prognosis
  • survival
  • title 19

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Turner, B. J., Denison, M., Eppes, S. C., Houchens, R., Fanning, T., & Markson, L. E. (1993). Survival experience of 789 children with the acquired immunodeficiency syndrome. Pediatric Infectious Disease Journal, 12(4), 310-320. https://doi.org/10.1097/00006454-199304000-00010