Survival experience of 789 children with the acquired immunodeficiency syndrome

B. J. Turner, M. Denison, S. C. Eppes, R. Houchens, T. Fanning, L. E. Markson

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

To define predictors of survival we studied longitudinal histories of 789 New York State Medicaid-enrolled children diagnosed with acquired immunodeficiency syndrome (AIDS) from 1983 to 1989 and followed through 1990. Median survival times for 3 severity groups of AIDS-defining conditions were 66, 48 and 9 months. In a proportional hazards model, the relative risk of death for the most vs. least severe group was 3.33 (95% confidence interval, 2.53, 4.37) and the relative risk for children <6 months old at diagnosis vs. older children was 1.81 (95% confidence interval, 1.41, 2.34). We increased our ability to predict death by using a 4-category severity index that assesses both the AIDS-defining diagnosis and clinical complications within 3 months of diagnosis (relative risk, 5.27; 95% confidence interval, 3.16, 8.78 for most vs. least severe). These analyses offer new clinical severity measures and reveal that, regardless of the AIDS-defining diagnosis, children with AIDS who are <6 months old have a poor prognosis.

Original languageEnglish (US)
Pages (from-to)310-320
Number of pages11
JournalPediatric Infectious Disease Journal
Volume12
Issue number4
StatePublished - 1993
Externally publishedYes

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Acquired Immunodeficiency Syndrome
Confidence Intervals
Medicaid
Proportional Hazards Models

Keywords

  • acquired immunodeficiency syndrome
  • child
  • infant
  • Medicaid
  • medical assistance
  • prognosis
  • Severity of illness
  • survival
  • title 19

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health

Cite this

Turner, B. J., Denison, M., Eppes, S. C., Houchens, R., Fanning, T., & Markson, L. E. (1993). Survival experience of 789 children with the acquired immunodeficiency syndrome. Pediatric Infectious Disease Journal, 12(4), 310-320.

Survival experience of 789 children with the acquired immunodeficiency syndrome. / Turner, B. J.; Denison, M.; Eppes, S. C.; Houchens, R.; Fanning, T.; Markson, L. E.

In: Pediatric Infectious Disease Journal, Vol. 12, No. 4, 1993, p. 310-320.

Research output: Contribution to journalArticle

Turner, BJ, Denison, M, Eppes, SC, Houchens, R, Fanning, T & Markson, LE 1993, 'Survival experience of 789 children with the acquired immunodeficiency syndrome', Pediatric Infectious Disease Journal, vol. 12, no. 4, pp. 310-320.
Turner BJ, Denison M, Eppes SC, Houchens R, Fanning T, Markson LE. Survival experience of 789 children with the acquired immunodeficiency syndrome. Pediatric Infectious Disease Journal. 1993;12(4):310-320.
Turner, B. J. ; Denison, M. ; Eppes, S. C. ; Houchens, R. ; Fanning, T. ; Markson, L. E. / Survival experience of 789 children with the acquired immunodeficiency syndrome. In: Pediatric Infectious Disease Journal. 1993 ; Vol. 12, No. 4. pp. 310-320.
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