Surgical treatment of lung cancer: Predicting postoperative morbidity in the elderly population

Natasha M. Rueth, Helen M. Parsons, Elizabeth B. Habermann, Shawn S. Groth, Beth A. Virnig, Todd M. Tuttle, Rafael S. Andrade, Michael A. Maddaus, Jonathan D'Cunha

Research output: Contribution to journalArticle

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Abstract

Objectives: Surgical resection is standard treatment for early-stage non-small cell lung cancer; however, perception of postoperative risk may influence the decision to proceed for elderly patients. With population data, we analyzed postoperative complications and morbidity predictors for older patients undergoing lobectomy for stage I non-small cell lung cancer. Methods: The Surveillance Epidemiology and End-Results-Medicare linked database (2000-2005) identified patients (ages 66-80 years) undergoing lobectomy for stage I non-small cell lung cancer. We comprehensively evaluated in-hospital postoperative complications (pulmonary, cardiac, infectious, noncardiopulmonary) with International Classification of Diseases, Ninth Revision, diagnosis codes. Logistic regression models were constructed to identify patient, tumor, and treatment characteristics associated with complications. Results: In all, 4171 patients were included, 2329 of whom had 4097 in-hospital postoperative complications (55.8%). Pulmonary complications were most common (n = 1598; 38.3%) followed by cardiac (n = 1020; 24.5%). Complications were significantly associated with age at least 75 years, male sex, higher comorbidity index, larger tumors, and treatment at nonteaching hospitals (P < .05). Patients with complications had a longer median stay (8 days) than patients without (6 days; P < .001). The 30-day mortality was 4.2%. Conclusions: Population-based analysis demonstrated that perioperative complications after lobectomy for stage I non-small cell lung cancer in older patients exceeded 50% and were associated with specific patient, tumor, and treatment characteristics. Better understanding of the impact of these risk factors may facilitate surgical decision making and encourage implementation of more effective perioperative care guidelines for older surgical patients.

Original languageEnglish (US)
Pages (from-to)1314-1323
Number of pages10
JournalJournal of Thoracic and Cardiovascular Surgery
Volume143
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

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Lung Neoplasms
Morbidity
Population
Non-Small Cell Lung Carcinoma
Therapeutics
Logistic Models
Perioperative Care
Neoplasms
Lung
International Classification of Diseases
Medicare
Comorbidity
Decision Making
Epidemiology
Databases
Guidelines
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Rueth, N. M., Parsons, H. M., Habermann, E. B., Groth, S. S., Virnig, B. A., Tuttle, T. M., ... D'Cunha, J. (2012). Surgical treatment of lung cancer: Predicting postoperative morbidity in the elderly population. Journal of Thoracic and Cardiovascular Surgery, 143(6), 1314-1323. https://doi.org/10.1016/j.jtcvs.2011.09.072

Surgical treatment of lung cancer : Predicting postoperative morbidity in the elderly population. / Rueth, Natasha M.; Parsons, Helen M.; Habermann, Elizabeth B.; Groth, Shawn S.; Virnig, Beth A.; Tuttle, Todd M.; Andrade, Rafael S.; Maddaus, Michael A.; D'Cunha, Jonathan.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 143, No. 6, 06.2012, p. 1314-1323.

Research output: Contribution to journalArticle

Rueth, NM, Parsons, HM, Habermann, EB, Groth, SS, Virnig, BA, Tuttle, TM, Andrade, RS, Maddaus, MA & D'Cunha, J 2012, 'Surgical treatment of lung cancer: Predicting postoperative morbidity in the elderly population', Journal of Thoracic and Cardiovascular Surgery, vol. 143, no. 6, pp. 1314-1323. https://doi.org/10.1016/j.jtcvs.2011.09.072
Rueth, Natasha M. ; Parsons, Helen M. ; Habermann, Elizabeth B. ; Groth, Shawn S. ; Virnig, Beth A. ; Tuttle, Todd M. ; Andrade, Rafael S. ; Maddaus, Michael A. ; D'Cunha, Jonathan. / Surgical treatment of lung cancer : Predicting postoperative morbidity in the elderly population. In: Journal of Thoracic and Cardiovascular Surgery. 2012 ; Vol. 143, No. 6. pp. 1314-1323.
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abstract = "Objectives: Surgical resection is standard treatment for early-stage non-small cell lung cancer; however, perception of postoperative risk may influence the decision to proceed for elderly patients. With population data, we analyzed postoperative complications and morbidity predictors for older patients undergoing lobectomy for stage I non-small cell lung cancer. Methods: The Surveillance Epidemiology and End-Results-Medicare linked database (2000-2005) identified patients (ages 66-80 years) undergoing lobectomy for stage I non-small cell lung cancer. We comprehensively evaluated in-hospital postoperative complications (pulmonary, cardiac, infectious, noncardiopulmonary) with International Classification of Diseases, Ninth Revision, diagnosis codes. Logistic regression models were constructed to identify patient, tumor, and treatment characteristics associated with complications. Results: In all, 4171 patients were included, 2329 of whom had 4097 in-hospital postoperative complications (55.8{\%}). Pulmonary complications were most common (n = 1598; 38.3{\%}) followed by cardiac (n = 1020; 24.5{\%}). Complications were significantly associated with age at least 75 years, male sex, higher comorbidity index, larger tumors, and treatment at nonteaching hospitals (P < .05). Patients with complications had a longer median stay (8 days) than patients without (6 days; P < .001). The 30-day mortality was 4.2{\%}. Conclusions: Population-based analysis demonstrated that perioperative complications after lobectomy for stage I non-small cell lung cancer in older patients exceeded 50{\%} and were associated with specific patient, tumor, and treatment characteristics. Better understanding of the impact of these risk factors may facilitate surgical decision making and encourage implementation of more effective perioperative care guidelines for older surgical patients.",
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AU - Parsons, Helen M.

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AU - Groth, Shawn S.

AU - Virnig, Beth A.

AU - Tuttle, Todd M.

AU - Andrade, Rafael S.

AU - Maddaus, Michael A.

AU - D'Cunha, Jonathan

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N2 - Objectives: Surgical resection is standard treatment for early-stage non-small cell lung cancer; however, perception of postoperative risk may influence the decision to proceed for elderly patients. With population data, we analyzed postoperative complications and morbidity predictors for older patients undergoing lobectomy for stage I non-small cell lung cancer. Methods: The Surveillance Epidemiology and End-Results-Medicare linked database (2000-2005) identified patients (ages 66-80 years) undergoing lobectomy for stage I non-small cell lung cancer. We comprehensively evaluated in-hospital postoperative complications (pulmonary, cardiac, infectious, noncardiopulmonary) with International Classification of Diseases, Ninth Revision, diagnosis codes. Logistic regression models were constructed to identify patient, tumor, and treatment characteristics associated with complications. Results: In all, 4171 patients were included, 2329 of whom had 4097 in-hospital postoperative complications (55.8%). Pulmonary complications were most common (n = 1598; 38.3%) followed by cardiac (n = 1020; 24.5%). Complications were significantly associated with age at least 75 years, male sex, higher comorbidity index, larger tumors, and treatment at nonteaching hospitals (P < .05). Patients with complications had a longer median stay (8 days) than patients without (6 days; P < .001). The 30-day mortality was 4.2%. Conclusions: Population-based analysis demonstrated that perioperative complications after lobectomy for stage I non-small cell lung cancer in older patients exceeded 50% and were associated with specific patient, tumor, and treatment characteristics. Better understanding of the impact of these risk factors may facilitate surgical decision making and encourage implementation of more effective perioperative care guidelines for older surgical patients.

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