Surfactant supplementation in the lung

Research output: Contribution to journalArticle

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Abstract

Alterations in pulmonary surfactant is an important contributing factor in the pathogenesis of ARDS. Surfactant deficiency affects the progression and prognosis of ARDS patients and increases the susceptibility of ARDS in patients who are at risk for it. Several studies have suggested that the use of exogenous surfactant preparations can improve lung function and overall outcome in ARDS patients; however, large randomized clinical trials have failed to show any benefit. Continued work on surfactant therapy-including efforts to improve the mode of delivery, to understand better the pathophysiology of exogenous surfactant, and to develop synthetic surfactants that emulate natural ones more closely-will help to elucidate its role in ARDS.

Original languageEnglish (US)
Pages (from-to)211-236
Number of pages26
JournalRespiratory care clinics of North America
Volume8
Issue number2
DOIs
StatePublished - Jan 1 2002

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ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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