Surface roughness modulates the response of MG63 osteoblast-like cells to vitamin D3 stimulation

K. Kieswetter; R. Batzer; Y. Liu; Z. Schwartz; D. Cochran; D. D. Dean; S. Szmuckler; J. Simpson; B. D. Boyan

Surface roughness modulates the response of MG63 osteoblast-like cells to vitamin D₃ stimulation

K. Kieswetter, R. Batzer, Y. Liu, Z. Schwartz, D. Cochran, D. D. Dean, S. Szmuckler, J. Simpson, B. D. Boyan

Research output: Contribution to conference › Paper › peer-review

Abstract

The effect of titanium surface roughness on the response of MG63 osteoblasts to 1,25-(OH)₂D₃ was investigated. Titanium (Ti) discs of varying roughness were prepared from unalloyed grade 2 Ti. Mg-63 osteoblast-like cells were plated onto Ti disks or tissue culture polystyrene for controls, then 1,25-(OH)₂D₃ were added to the cultures for 24 hours. Surface roughness values were obtained using Taylor-Hobson Sutonic 3P profilometer. The enhance response of osteoblasts grown on the rougher surfaces with 1,25-(OH)₂D₃ stimulation supports the premise that osteoblast-like cells are more differentiated than those on smoother surfaces.

Original language	English (US)
Pages	941
Number of pages	1
State	Published - 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

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Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

General Materials Science

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title = "Surface roughness modulates the response of MG63 osteoblast-like cells to vitamin D3 stimulation",

abstract = "The effect of titanium surface roughness on the response of MG63 osteoblasts to 1,25-(OH)2D3 was investigated. Titanium (Ti) discs of varying roughness were prepared from unalloyed grade 2 Ti. Mg-63 osteoblast-like cells were plated onto Ti disks or tissue culture polystyrene for controls, then 1,25-(OH)2D3 were added to the cultures for 24 hours. Surface roughness values were obtained using Taylor-Hobson Sutonic 3P profilometer. The enhance response of osteoblasts grown on the rougher surfaces with 1,25-(OH)2D3 stimulation supports the premise that osteoblast-like cells are more differentiated than those on smoother surfaces.",

author = "K. Kieswetter and R. Batzer and Y. Liu and Z. Schwartz and D. Cochran and Dean, {D. D.} and S. Szmuckler and J. Simpson and Boyan, {B. D.}",

year = "1996",

language = "English (US)",

pages = "941",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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T1 - Surface roughness modulates the response of MG63 osteoblast-like cells to vitamin D3 stimulation

AU - Kieswetter, K.

AU - Batzer, R.

AU - Liu, Y.

AU - Schwartz, Z.

AU - Cochran, D.

AU - Dean, D. D.

AU - Szmuckler, S.

AU - Simpson, J.

AU - Boyan, B. D.

PY - 1996

Y1 - 1996

N2 - The effect of titanium surface roughness on the response of MG63 osteoblasts to 1,25-(OH)2D3 was investigated. Titanium (Ti) discs of varying roughness were prepared from unalloyed grade 2 Ti. Mg-63 osteoblast-like cells were plated onto Ti disks or tissue culture polystyrene for controls, then 1,25-(OH)2D3 were added to the cultures for 24 hours. Surface roughness values were obtained using Taylor-Hobson Sutonic 3P profilometer. The enhance response of osteoblasts grown on the rougher surfaces with 1,25-(OH)2D3 stimulation supports the premise that osteoblast-like cells are more differentiated than those on smoother surfaces.

AB - The effect of titanium surface roughness on the response of MG63 osteoblasts to 1,25-(OH)2D3 was investigated. Titanium (Ti) discs of varying roughness were prepared from unalloyed grade 2 Ti. Mg-63 osteoblast-like cells were plated onto Ti disks or tissue culture polystyrene for controls, then 1,25-(OH)2D3 were added to the cultures for 24 hours. Surface roughness values were obtained using Taylor-Hobson Sutonic 3P profilometer. The enhance response of osteoblasts grown on the rougher surfaces with 1,25-(OH)2D3 stimulation supports the premise that osteoblast-like cells are more differentiated than those on smoother surfaces.

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M3 - Paper

AN - SCOPUS:0030387399

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T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Surface roughness modulates the response of MG63 osteoblast-like cells to vitamin D₃ stimulation

Abstract

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