Surface roughness modulates the response of MG63 osteoblast-like cells to vitamin D3 stimulation

K. Kieswetter, R. Batzer, Y. Liu, Z. Schwartz, D. Cochran, D. D. Dean, S. Szmuckler, J. Simpson, B. D. Boyan

Research output: Contribution to conferencePaperpeer-review

Abstract

The effect of titanium surface roughness on the response of MG63 osteoblasts to 1,25-(OH)2D3 was investigated. Titanium (Ti) discs of varying roughness were prepared from unalloyed grade 2 Ti. Mg-63 osteoblast-like cells were plated onto Ti disks or tissue culture polystyrene for controls, then 1,25-(OH)2D3 were added to the cultures for 24 hours. Surface roughness values were obtained using Taylor-Hobson Sutonic 3P profilometer. The enhance response of osteoblasts grown on the rougher surfaces with 1,25-(OH)2D3 stimulation supports the premise that osteoblast-like cells are more differentiated than those on smoother surfaces.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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