Suppression of RIP3-dependent necroptosis by human cytomegalovirus

Shinya Omoto, Hongyan Guo, Ganesh R. Talekar, Linda Roback, William J. Kaiser, Edward S. Mocarski

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Background: Viral suppressors of RHIM-dependent activation of pro-necrotic RIP3 kinase are crucial for successful infection in mice. Results: Human CMV blocks TNF-induced and murine CMV-induced necroptosis after RIP3 activation. Conclusion: Necrotic membrane leakage is blocked in infected cells despite the activation of MLKL. Significance: Viral inhibition of necroptosis will facilitate understanding of the final steps in this pathway.

Original languageEnglish (US)
Pages (from-to)11635-11648
Number of pages14
JournalJournal of Biological Chemistry
Volume290
Issue number18
DOIs
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Omoto, S., Guo, H., Talekar, G. R., Roback, L., Kaiser, W. J., & Mocarski, E. S. (2015). Suppression of RIP3-dependent necroptosis by human cytomegalovirus. Journal of Biological Chemistry, 290(18), 11635-11648. https://doi.org/10.1074/jbc.M115.646042