Suppression of RIP3-dependent necroptosis by human cytomegalovirus

Shinya Omoto; Hongyan Guo; Ganesh R. Talekar; Linda Roback; William J. Kaiser; Edward S. Mocarski

doi:10.1074/jbc.M115.646042

Suppression of RIP3-dependent necroptosis by human cytomegalovirus

Shinya Omoto, Hongyan Guo, Ganesh R. Talekar, Linda Roback, William J. Kaiser, Edward S. Mocarski

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Background: Viral suppressors of RHIM-dependent activation of pro-necrotic RIP3 kinase are crucial for successful infection in mice. Results: Human CMV blocks TNF-induced and murine CMV-induced necroptosis after RIP3 activation. Conclusion: Necrotic membrane leakage is blocked in infected cells despite the activation of MLKL. Significance: Viral inhibition of necroptosis will facilitate understanding of the final steps in this pathway.

Original language	English (US)
Pages (from-to)	11635-11648
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M115.646042
State	Published - May 1 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.646042

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title = "Suppression of RIP3-dependent necroptosis by human cytomegalovirus",

abstract = "Background: Viral suppressors of RHIM-dependent activation of pro-necrotic RIP3 kinase are crucial for successful infection in mice. Results: Human CMV blocks TNF-induced and murine CMV-induced necroptosis after RIP3 activation. Conclusion: Necrotic membrane leakage is blocked in infected cells despite the activation of MLKL. Significance: Viral inhibition of necroptosis will facilitate understanding of the final steps in this pathway.",

author = "Shinya Omoto and Hongyan Guo and Talekar, {Ganesh R.} and Linda Roback and Kaiser, {William J.} and Mocarski, {Edward S.}",

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AU - Omoto, Shinya

AU - Guo, Hongyan

AU - Talekar, Ganesh R.

AU - Roback, Linda

AU - Kaiser, William J.

AU - Mocarski, Edward S.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Viral suppressors of RHIM-dependent activation of pro-necrotic RIP3 kinase are crucial for successful infection in mice. Results: Human CMV blocks TNF-induced and murine CMV-induced necroptosis after RIP3 activation. Conclusion: Necrotic membrane leakage is blocked in infected cells despite the activation of MLKL. Significance: Viral inhibition of necroptosis will facilitate understanding of the final steps in this pathway.

AB - Background: Viral suppressors of RHIM-dependent activation of pro-necrotic RIP3 kinase are crucial for successful infection in mice. Results: Human CMV blocks TNF-induced and murine CMV-induced necroptosis after RIP3 activation. Conclusion: Necrotic membrane leakage is blocked in infected cells despite the activation of MLKL. Significance: Viral inhibition of necroptosis will facilitate understanding of the final steps in this pathway.

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Suppression of RIP3-dependent necroptosis by human cytomegalovirus

Abstract

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