Abstract
Background: Viral suppressors of RHIM-dependent activation of pro-necrotic RIP3 kinase are crucial for successful infection in mice. Results: Human CMV blocks TNF-induced and murine CMV-induced necroptosis after RIP3 activation. Conclusion: Necrotic membrane leakage is blocked in infected cells despite the activation of MLKL. Significance: Viral inhibition of necroptosis will facilitate understanding of the final steps in this pathway.
Original language | English (US) |
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Pages (from-to) | 11635-11648 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 18 |
DOIs | |
State | Published - May 1 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology