Suppression of premature senescence and promotion of metastatic transformation: Role of reduced TGF-Beta signaling in human cancer progression

Shu Lin, Luzhe Sun

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Transforming growth factor-beta (TGF-β) signaling pathway serves as a tumor suppressor by inhibiting cell cycle progression and stimulating senescence and apoptosis in normal and early-stages neoplastic tissues. As tumors progress, TGF-β signaling is often turned to drive multi-step metastasis processes by stimulating cell survival and epithelial-tomesenchymal transition (EMT) leading to tumor cell migration and invasion. Many human carcinomas including triple-negative breast cancer, often show reduced or loss of key components of TGF-β signaling, indicating reduced tumor-suppressive TGF-β signaling may contribute to the cancer progression. However, molecular mechanisms that drive the switch of TGF-β are not well understood. Few molecular biomarkers have been identifi ed as effi cient indicators for the anti-TGF-β cancer therapy. In order to better understand the mechanism mediating the role of TGF-β during cancer progression, we will discuss the question of how the loss of control of cell proliferation and senescence by TGF-β promotes tumor invasion and metastasis and whether a set of transformation/metastasis-related genes are specifi cally regulated by TGF-β signaling.

Original languageEnglish (US)
Title of host publicationTumor Dormancy, Quiescence, and Senescence, Volume 2
Subtitle of host publicationAging, Cancer, and Noncancer Pathologies
PublisherSpringer Netherlands
Pages219-226
Number of pages8
ISBN (Electronic)9789400777262
ISBN (Print)9789400777255
DOIs
StatePublished - Jan 1 2014

Keywords

  • C-Myc transcription in epithelial cells
  • Co-expression of DNRII and H-Ras-V12
  • Human carcinomas
  • Human mammaryepithelial cells (HMECs)
  • R-Smads and Smad4
  • Senescence-like growth arrest (SLGA)
  • TGF-β1 inhibitor element (TIE)
  • TGF-β‘s growth inhibition
  • TGFBR2 mutation
  • Transforming growth factor-beta (TGF-β) signaling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Suppression of premature senescence and promotion of metastatic transformation: Role of reduced TGF-Beta signaling in human cancer progression'. Together they form a unique fingerprint.

Cite this