Suppression of oxygen toxicity by melatonin

Russel J Reiter, Dun Xian Tan, Wen Bo Qi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. While most studies to date have used pharmacological quantities of melatonin to limit oxidative damage, physiologic concentrations of the indole which are present in aerobic organisms have also been shown to resist molecular damage inflicted by free radicals. Melatonin has several functions in terms of its antioxidative ability. It readily scavenges the most highly toxic free radical, the hydroxyl radical, and it directly detoxifies the peroxynitrite anion, nitric oxide, singlet oxygen, and the peroxyl radical. Precisely how efficient melatonin is in neutralizing each of these toxic agents remains to be determined. Melatonin also may stimulate several antioxidative enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. Finally, melatonin chelates transition metal ions and prevents the deterioration of cellular membranes. This combination of actions may all contribute to melatonin's ability to reduce oxidative damage. Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo. These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage.

Original languageEnglish (US)
Pages (from-to)575-581
Number of pages7
JournalActa Pharmacologica Sinica
Volume19
Issue number6
StatePublished - Nov 1998

Fingerprint

Melatonin
Toxicity
Oxygen
Free Radicals
Poisons
Singlet Oxygen
Free Radical Scavengers
Peroxynitrous Acid
Pineal Gland
Glutathione Reductase
Enzymes
Membrane Lipids
Glutathione Peroxidase
Nitric Oxide Synthase
Neurodegenerative Diseases
Hydroxyl Radical
DNA Damage
Superoxide Dismutase
Transition metals
Anions

Keywords

  • Aging
  • Antioxidants
  • Free radicals
  • Melatonin
  • Oxidative stress

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology

Cite this

Suppression of oxygen toxicity by melatonin. / Reiter, Russel J; Tan, Dun Xian; Qi, Wen Bo.

In: Acta Pharmacologica Sinica, Vol. 19, No. 6, 11.1998, p. 575-581.

Research output: Contribution to journalArticle

Reiter, RJ, Tan, DX & Qi, WB 1998, 'Suppression of oxygen toxicity by melatonin', Acta Pharmacologica Sinica, vol. 19, no. 6, pp. 575-581.
Reiter, Russel J ; Tan, Dun Xian ; Qi, Wen Bo. / Suppression of oxygen toxicity by melatonin. In: Acta Pharmacologica Sinica. 1998 ; Vol. 19, No. 6. pp. 575-581.
@article{16a7482da8d84a4dab0f6fabb7887e12,
title = "Suppression of oxygen toxicity by melatonin",
abstract = "Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. While most studies to date have used pharmacological quantities of melatonin to limit oxidative damage, physiologic concentrations of the indole which are present in aerobic organisms have also been shown to resist molecular damage inflicted by free radicals. Melatonin has several functions in terms of its antioxidative ability. It readily scavenges the most highly toxic free radical, the hydroxyl radical, and it directly detoxifies the peroxynitrite anion, nitric oxide, singlet oxygen, and the peroxyl radical. Precisely how efficient melatonin is in neutralizing each of these toxic agents remains to be determined. Melatonin also may stimulate several antioxidative enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. Finally, melatonin chelates transition metal ions and prevents the deterioration of cellular membranes. This combination of actions may all contribute to melatonin's ability to reduce oxidative damage. Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo. These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage.",
keywords = "Aging, Antioxidants, Free radicals, Melatonin, Oxidative stress",
author = "Reiter, {Russel J} and Tan, {Dun Xian} and Qi, {Wen Bo}",
year = "1998",
month = "11",
language = "English (US)",
volume = "19",
pages = "575--581",
journal = "Acta Pharmacologica Sinica",
issn = "1671-4083",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Suppression of oxygen toxicity by melatonin

AU - Reiter, Russel J

AU - Tan, Dun Xian

AU - Qi, Wen Bo

PY - 1998/11

Y1 - 1998/11

N2 - Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. While most studies to date have used pharmacological quantities of melatonin to limit oxidative damage, physiologic concentrations of the indole which are present in aerobic organisms have also been shown to resist molecular damage inflicted by free radicals. Melatonin has several functions in terms of its antioxidative ability. It readily scavenges the most highly toxic free radical, the hydroxyl radical, and it directly detoxifies the peroxynitrite anion, nitric oxide, singlet oxygen, and the peroxyl radical. Precisely how efficient melatonin is in neutralizing each of these toxic agents remains to be determined. Melatonin also may stimulate several antioxidative enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. Finally, melatonin chelates transition metal ions and prevents the deterioration of cellular membranes. This combination of actions may all contribute to melatonin's ability to reduce oxidative damage. Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo. These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage.

AB - Melatonin, the chief secretory product of the pineal gland, was recently found to be a free radical scavenger and antioxidant. While most studies to date have used pharmacological quantities of melatonin to limit oxidative damage, physiologic concentrations of the indole which are present in aerobic organisms have also been shown to resist molecular damage inflicted by free radicals. Melatonin has several functions in terms of its antioxidative ability. It readily scavenges the most highly toxic free radical, the hydroxyl radical, and it directly detoxifies the peroxynitrite anion, nitric oxide, singlet oxygen, and the peroxyl radical. Precisely how efficient melatonin is in neutralizing each of these toxic agents remains to be determined. Melatonin also may stimulate several antioxidative enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase as well as inhibiting the pro-oxidative enzyme, nitric-oxide synthase. Finally, melatonin chelates transition metal ions and prevents the deterioration of cellular membranes. This combination of actions may all contribute to melatonin's ability to reduce oxidative damage. Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo. These findings have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage.

KW - Aging

KW - Antioxidants

KW - Free radicals

KW - Melatonin

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=0031743140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031743140&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 575

EP - 581

JO - Acta Pharmacologica Sinica

JF - Acta Pharmacologica Sinica

SN - 1671-4083

IS - 6

ER -