Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist

A. H. Costello; K. M. Hargreaves

doi:10.1016/0014-2999(89)90118-0

Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist

A. H. Costello, K. M. Hargreaves

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocke carrageenan-induced hyperalgesia, hyperthermia and edena. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.

Original language	English (US)
Pages (from-to)	259-263
Number of pages	5
Journal	European Journal of Pharmacology
Volume	171
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(89)90118-0
State	Published - Nov 21 1989
Externally published	Yes

Keywords

Bradykinin
Carrageenan
Inflammation
NPC567

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(89)90118-0

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title = "Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist",

abstract = "Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocke carrageenan-induced hyperalgesia, hyperthermia and edena. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.",

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AU - Costello, A. H.

AU - Hargreaves, K. M.

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Y1 - 1989/11/21

N2 - Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocke carrageenan-induced hyperalgesia, hyperthermia and edena. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.

AB - Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocke carrageenan-induced hyperalgesia, hyperthermia and edena. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.

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KW - Inflammation

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