Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist

A. H. Costello, K. M. Hargreaves

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocke carrageenan-induced hyperalgesia, hyperthermia and edena. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.

Original languageEnglish (US)
Pages (from-to)259-263
Number of pages5
JournalEuropean Journal of Pharmacology
Volume171
Issue number2-3
DOIs
StatePublished - Nov 21 1989
Externally publishedYes

Keywords

  • Bradykinin
  • Carrageenan
  • Inflammation
  • NPC567

ASJC Scopus subject areas

  • Pharmacology

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