Abstract
Although bradykinin (BK) antagonists have antinociceptive effects, they have not been evaluated for anti-inflammatory activity. When administered with carrageenan into the rat hindpaw, NPC567 significantly blocke carrageenan-induced hyperalgesia, hyperthermia and edena. In addition, NPC567 did not alter the in vitro release of immunoreactive BK by plasma kallikrein. These results indicate that the antinociceptive activity of NPC567, a BK antagonist, may be related to its overall anti-inflammatory activity and that is mechanism of action does not include inhibition of plasma kallikrein.
Original language | English (US) |
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Pages (from-to) | 259-263 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 171 |
Issue number | 2-3 |
DOIs | |
State | Published - Nov 21 1989 |
Externally published | Yes |
Keywords
- Bradykinin
- Carrageenan
- Inflammation
- NPC567
ASJC Scopus subject areas
- Pharmacology