[99mTc] Liposomes for localizing experimental colitis in a rabbit model

Vibhudutta Awasthi; Beth Goins; Linda McManus; Robert Klipper; William T. Phillips

doi:10.1016/S0969-8051(02)00419-5

[^99mTc] Liposomes for localizing experimental colitis in a rabbit model

Vibhudutta Awasthi, Beth Goins, Linda McManus, Robert Klipper, William T. Phillips

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

[^99mTc] liposomes (TL) and [¹¹¹In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [^99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [¹¹¹In] WBCs. The study demonstrates the usefulness of [^99mTc] liposomes for imaging inflammatory bowel diseases.

Original language	English (US)
Pages (from-to)	159-168
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/S0969-8051(02)00419-5
State	Published - Feb 2003

Keywords

Colitis
Drug delivery
Indium-111
Inflammation
Inflammatory bowel disease
Liposomes
Technetium-99m

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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title = "[99mTc] Liposomes for localizing experimental colitis in a rabbit model",

abstract = "[99mTc] liposomes (TL) and [111In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [111In] WBCs. The study demonstrates the usefulness of [99mTc] liposomes for imaging inflammatory bowel diseases.",

keywords = "Colitis, Drug delivery, Indium-111, Inflammation, Inflammatory bowel disease, Liposomes, Technetium-99m",

author = "Vibhudutta Awasthi and Beth Goins and Linda McManus and Robert Klipper and Phillips, {William T.}",

note = "Funding Information: The authors acknowledge the help of Dr. Alan Rudolph and Richard Cliff at the Naval Research Laboratory, Washington DC for determining the size of the liposomes. The contribution of Dr. Ronald Crawley for performing pathological examination is also acknowledged. This study was funded by a grant from the National Institutes of Health (RO1 HL 53052). ",

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AU - Awasthi, Vibhudutta

AU - Goins, Beth

AU - McManus, Linda

AU - Klipper, Robert

AU - Phillips, William T.

N1 - Funding Information: The authors acknowledge the help of Dr. Alan Rudolph and Richard Cliff at the Naval Research Laboratory, Washington DC for determining the size of the liposomes. The contribution of Dr. Ronald Crawley for performing pathological examination is also acknowledged. This study was funded by a grant from the National Institutes of Health (RO1 HL 53052).

PY - 2003/2

Y1 - 2003/2

N2 - [99mTc] liposomes (TL) and [111In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [111In] WBCs. The study demonstrates the usefulness of [99mTc] liposomes for imaging inflammatory bowel diseases.

AB - [99mTc] liposomes (TL) and [111In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [111In] WBCs. The study demonstrates the usefulness of [99mTc] liposomes for imaging inflammatory bowel diseases.

KW - Colitis

KW - Drug delivery

KW - Indium-111

KW - Inflammation

KW - Inflammatory bowel disease

KW - Liposomes

KW - Technetium-99m

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