[99mTc] Liposomes for localizing experimental colitis in a rabbit model

Vibhudutta Awasthi, Beth Goins, Linda McManus, Robert Klipper, William T. Phillips

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

[99mTc] liposomes (TL) and [111In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [111In] WBCs. The study demonstrates the usefulness of [99mTc] liposomes for imaging inflammatory bowel diseases.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalNuclear Medicine and Biology
Volume30
Issue number2
DOIs
StatePublished - Feb 2003

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Keywords

  • Colitis
  • Drug delivery
  • Indium-111
  • Inflammation
  • Inflammatory bowel disease
  • Liposomes
  • Technetium-99m

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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