Abstract
[99mTc] liposomes (TL) and [111In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [111In] WBCs. The study demonstrates the usefulness of [99mTc] liposomes for imaging inflammatory bowel diseases.
Original language | English (US) |
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Pages (from-to) | 159-168 |
Number of pages | 10 |
Journal | Nuclear Medicine and Biology |
Volume | 30 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2003 |
Keywords
- Colitis
- Drug delivery
- Indium-111
- Inflammation
- Inflammatory bowel disease
- Liposomes
- Technetium-99m
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research