[99mTc] Liposomes for localizing experimental colitis in a rabbit model

Vibhudutta Awasthi; Beth Goins; Linda McManus; Robert Klipper; William T. Phillips

doi:10.1016/S0969-8051(02)00419-5

[^99mTc] Liposomes for localizing experimental colitis in a rabbit model

Vibhudutta Awasthi, Beth Goins, Linda McManus, Robert Klipper, William T. Phillips

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

[^99mTc] liposomes (TL) and [¹¹¹In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [^99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [¹¹¹In] WBCs. The study demonstrates the usefulness of [^99mTc] liposomes for imaging inflammatory bowel diseases.

Original language	English (US)
Pages (from-to)	159-168
Number of pages	10
Journal	Nuclear Medicine and Biology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/S0969-8051(02)00419-5
State	Published - Feb 2003

Keywords

Colitis
Drug delivery
Indium-111
Inflammation
Inflammatory bowel disease
Liposomes
Technetium-99m

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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title = "[99mTc] Liposomes for localizing experimental colitis in a rabbit model",

abstract = "[99mTc] liposomes (TL) and [111In]WBCs (WBCs) were compared for imaging colitis in rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs), besides blood (44.1% TL vs 24.4% WBCs) and spleen (0.3% TL vs 7% WBCs). The inflamed colon accumulated 37.1 times more of [99mTc] liposomes than the normal colon whereas the ratio was only 15.2 in case of [111In] WBCs. The study demonstrates the usefulness of [99mTc] liposomes for imaging inflammatory bowel diseases.",

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AU - Phillips, William T.

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